ethyl 2-phenyl-5-(3-(tetrahydro-2H-pyran-2-yloxy)prop-1-ynyl)thiazole-4-carboxylate

Base Information

• Chemical Name: ethyl 2-phenyl-5-(3-(tetrahydro-2H-pyran-2-yloxy)prop-1-ynyl)thiazole-4-carboxylate
• CAS No.: 1231952-94-5
• Molecular Formula: C₂₀H₂₁NO₄S
• Molecular Weight: 371.457
• Mol file: 1231952-94-5.mol

Synonyms:ethyl 2-phenyl-5-(3-(tetrahydro-2H-pyran-2-yloxy)prop-1-ynyl)thiazole-4-carboxylate

Chemical Property of ethyl 2-phenyl-5-(3-(tetrahydro-2H-pyran-2-yloxy)prop-1-ynyl)thiazole-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of ethyl 2-phenyl-5-(3-(tetrahydro-2H-pyran-2-yloxy)prop-1-ynyl)thiazole-4-carboxylate

There total 1 articles about ethyl 2-phenyl-5-(3-(tetrahydro-2H-pyran-2-yloxy)prop-1-ynyl)thiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

ethyl 5-bromo-2-phenylthiazole-4-carboxylate (914347-21-0) + 3-(tetrahydropyran-2'-yloxy)propyne (6089-04-9) → ethyl 2-phenyl-5-(3-(tetrahydro-2H-pyran-2-yloxy)prop-1-ynyl)thiazole-4-carboxylate (1231952-94-5)

Guidance literature:

With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; at 100 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

Reference yield:

methanol (67-56-1) + ethyl 2-phenyl-5-(3-(tetrahydro-2H-pyran-2-yloxy)prop-1-ynyl)thiazole-4-carboxylate (1231952-94-5) → C14H15NO3S (1231952-96-7) + C15H17NO3S (1231952-95-6)

Guidance literature:

ethyl 2-phenyl-5-(3-(tetrahydro-2H-pyran-2-yloxy)prop-1-ynyl)thiazole-4-carboxylate; With hydrogen; 1% Pd/C; In tetrahydrofuran; methanol; for 96h;

methanol; toluene-4-sulfonic acid; for 16h;

With sodium hydrogencarbonate; In water; ethyl acetate;

upstream raw materials:

ethyl 5-bromo-2-phenylthiazole-4-carboxylate

3-(tetrahydropyran-2'-yloxy)propyne

Downstream raw materials:

C₁₄H₁₅NO₃S

C₁₅H₁₇NO₃S