Benzyloxycarbonyl-L-phenylalanyl-L-lysyl-PABC-4-fluorodeacetylcolchicine

Base Information

Chemical Name:Benzyloxycarbonyl-L-phenylalanyl-L-lysyl-PABC-4-fluorodeacetylcolchicine
CAS No.:1279111-09-9
Molecular Formula:C₅₁H₅₆FN₅O₁₁
Molecular Weight:934.031
Hs Code.:

Synonyms:Benzyloxycarbonyl-L-phenylalanyl-L-lysyl-PABC-4-fluorodeacetylcolchicine

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Chemical Property of Benzyloxycarbonyl-L-phenylalanyl-L-lysyl-PABC-4-fluorodeacetylcolchicine

Chemical Property:

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Technology Process of Benzyloxycarbonyl-L-phenylalanyl-L-lysyl-PABC-4-fluorodeacetylcolchicine

There total 14 articles about Benzyloxycarbonyl-L-phenylalanyl-L-lysyl-PABC-4-fluorodeacetylcolchicine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1279111-12-4
C₅₅H₆₀FN₅O₁₃

: 1279111-09-9
Benzyloxycarbonyl-L-phenylalanyl-L-lysyl-PABC-4-fluorodeacetylcolchicine

Guidance literature:: With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran;
DOI:10.1021/ml100287y

Reference yield:

: 6298-03-9,274260-42-3
(2S)-2-amino-6-{[(prop-2-en-1-yloxy)carbonyl]amino}hexanoic acid

: 1279111-09-9
Benzyloxycarbonyl-L-phenylalanyl-L-lysyl-PABC-4-fluorodeacetylcolchicine

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate / 1,2-dimethoxyethane; water

2: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran

3: pyridine / tetrahydrofuran

4: triethylamine / 1-methyl-pyrrolidin-2-one

5: morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran

With morpholine; 4-methyl-morpholine; pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; water;
DOI:10.1021/ml100287y

Reference yield:

: 1161-13-3
N-Cbz-L-Phe

: 1279111-09-9
Benzyloxycarbonyl-L-phenylalanyl-L-lysyl-PABC-4-fluorodeacetylcolchicine

Guidance literature:: Multi-step reaction with 6 steps

1: dicyclohexyl-carbodiimide / tetrahydrofuran

2: sodium hydrogencarbonate / 1,2-dimethoxyethane; water

3: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran

4: pyridine / tetrahydrofuran

5: triethylamine / 1-methyl-pyrrolidin-2-one

6: morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran

With morpholine; 4-methyl-morpholine; pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; water;
DOI:10.1021/ml100287y