1279111-12-4

Basic information

• Product Name: C₅₅H₆₀FN₅O₁₃
• Synonyms: C₅₅H₆₀FN₅O₁₃
• CAS NO: 1279111-12-4
• Molecular Weight: 1018.11
• Mol File: 1279111-12-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₅₅H₆₀FN₅O₁₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₅₅H₆₀FN₅O₁₃(1279111-12-4)
• EPA Substance Registry System: C₅₅H₆₀FN₅O₁₃(1279111-12-4)

Safety Data

• Hazardous Substances Data: 1279111-12-4(Hazardous Substances Data)

Upstream product

• 159857-89-3 N-Cbz-Phe-Lys(ε-Alloc)-4-aminobenzyl alcohol 
• 159857-88-2 N-Cbz-Phe-Lys(ε-Alloc)OH 
• 501-53-1 benzyl chloroformate 
• 64-86-8 colchicine 
• 1161-13-3 N-Cbz-L-Phe 
• 63-91-2 L-phenylalanine 
• 6298-03-9 (2S)-2-amino-6-{[(prop-2-en-1-yloxy)carbonyl]amino}hexanoic acid 
• 56-87-1 L-lysine 
• 3397-32-8 N-(benzyloxycarbonyl)-phenylalanine-N-hydroxysuccinimide ester 
• 1267986-43-5 C₂₅H₃₀FNO₇ 
• 1267986-41-3 4-fluoro-N-(t-butoxycarbonyl)colchicine 
• 1267986-31-1 4-Fluorocolchicine 
• 1267986-45-7 4-Fluorodeacetylcolchicine 
• 159857-90-6 N-Cbz-Phe-Lys(ε-Alloc)-4-aminobenzyl 4-nitrophenyl carbonate 

Downstream Products

• 1267986-45-7 4-Fluorodeacetylcolchicine 
• 71448-16-3 Cbz-L-Phe-L-Lys-OH 
• 1279111-09-9 Benzyloxycarbonyl-L-phenylalanyl-L-lysyl-PABC-4-fluorodeacetylcolchicine 

Relevant articles and documents

Design, synthesis, and antitumor activity of 4-halocolchicines and their pro-drugs activated by cathepsin B

Novel colchicine derivatives possessing various substituents at the C4 position were prepared. Among them, 4-halo derivatives 3-6 were found to exhibit higher activity against cancer cell lines (A549, HT29, HCT116) as well as on mice transplanted with the HCT116 human colorectal carcinoma cell line than colchicine (1). Further, utilizing the 4-substituted colchicines, we prepared pro-drugs having a dipeptide side chain and demonstrated that these pro-drugs were activated by cathepsin B, an enzyme overexpressed in tumor cells, and exhibited selective toxicity to the tumor cells.