1-(4-(5-amino-2-(pyridin-2-yl)thiazolo[5,4-d]pyrimidin-7-yl)piperazin-1-yl)-2-(4-chlorophenoxy)ethanone

Base Information

• Chemical Name: 1-(4-(5-amino-2-(pyridin-2-yl)thiazolo[5,4-d]pyrimidin-7-yl)piperazin-1-yl)-2-(4-chlorophenoxy)ethanone
• CAS No.: 1245320-09-5
• Molecular Formula: C₂₂H₂₀ClN₇O₂S
• Molecular Weight: 481.966

Synonyms:1-(4-(5-amino-2-(pyridin-2-yl)thiazolo[5,4-d]pyrimidin-7-yl)piperazin-1-yl)-2-(4-chlorophenoxy)ethanone

Chemical Property of 1-(4-(5-amino-2-(pyridin-2-yl)thiazolo[5,4-d]pyrimidin-7-yl)piperazin-1-yl)-2-(4-chlorophenoxy)ethanone

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Technology Process of 1-(4-(5-amino-2-(pyridin-2-yl)thiazolo[5,4-d]pyrimidin-7-yl)piperazin-1-yl)-2-(4-chlorophenoxy)ethanone

There total 4 articles about 1-(4-(5-amino-2-(pyridin-2-yl)thiazolo[5,4-d]pyrimidin-7-yl)piperazin-1-yl)-2-(4-chlorophenoxy)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

7-(piperazin-1-yl)-2-(pyridin-2-yl)thiazolo[5,4-d]pyrimidin-5-amine (1245319-95-2) + 4-chlorophenyloxyacetyl chloride (4122-68-3) → 1-(4-(5-amino-2-(pyridin-2-yl)thiazolo[5,4-d]pyrimidin-7-yl)piperazin-1-yl)-2-(4-chlorophenoxy)ethanone (1245320-09-5)

Guidance literature:

With pyridine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1021/jm101254z

Reference yield:

pyridine-2-carbaldehyde (1121-60-4) → 1-(4-(5-amino-2-(pyridin-2-yl)thiazolo[5,4-d]pyrimidin-7-yl)piperazin-1-yl)-2-(4-chlorophenoxy)ethanone (1245320-09-5)

Guidance literature:

Multi-step reaction with 3 steps

1: dimethyl sulfoxide / 1 h / 150 °C

2: trifluoroacetic acid / dichloromethane / 20 °C

3: pyridine / N,N-dimethyl-formamide / 2 h / 20 °C

With pyridine; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/jm101254z

Reference yield:

tert-butyl 4-(2,5-diamino-6-mercaptopyrimidin-4-yl)piperazine-1-carboxylate (1245319-93-0) → 1-(4-(5-amino-2-(pyridin-2-yl)thiazolo[5,4-d]pyrimidin-7-yl)piperazin-1-yl)-2-(4-chlorophenoxy)ethanone (1245320-09-5)

Guidance literature:

Multi-step reaction with 3 steps

1: dimethyl sulfoxide / 1 h / 150 °C

2: trifluoroacetic acid / dichloromethane / 20 °C

3: pyridine / N,N-dimethyl-formamide / 2 h / 20 °C

With pyridine; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/jm101254z

upstream raw materials:

pyridine-2-carbaldehyde

7-(piperazin-1-yl)-2-(pyridin-2-yl)thiazolo[5,4-d]pyrimidin-5-amine

4-chlorophenyloxyacetyl chloride

tert-butyl 4-(2,5-diamino-6-chloropyrimidin-4-yl)piperazine-1-carboxylate

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