5'-O-(4,4'-dimethoxytrityl)-2'-methoxyoxalylamido-2'-deoxyuridine

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxytrityl)-2'-methoxyoxalylamido-2'-deoxyuridine
• CAS No.: 177980-12-0
• Molecular Formula: C₃₃H₃₃N₃O₁₀
• Molecular Weight: 631.639
• Mol file: 177980-12-0.mol

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2'-methoxyoxalylamido-2'-deoxyuridine

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2'-methoxyoxalylamido-2'-deoxyuridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2'-methoxyoxalylamido-2'-deoxyuridine

There total 8 articles about 5'-O-(4,4'-dimethoxytrityl)-2'-methoxyoxalylamido-2'-deoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

Dimethyl oxalate (553-90-2) + dichloromethane (75-09-2) + 5'-O-dimethoxytrityl-2'-amino-2'-deoxyuridine (174221-86-4) → 5'-O-(4,4'-dimethoxytrityl)-2'-methoxyoxalylamido-2'-deoxyuridine (177980-12-0)

Guidance literature:

In methanol;

Reference yield: 79.5%

monomethyl oxalyl chloride (5781-53-3) + 2,4,6-trimethyl-pyridine (108-75-8) + methyl oxalyl tetrazolide + 5'-O-dimethoxytrityl-2'-amino-2'-deoxyuridine (174221-86-4) → 5'-O-(4,4'-dimethoxytrityl)-2'-methoxyoxalylamido-2'-deoxyuridine (177980-12-0)

Guidance literature:

With sulfuric acid; nitrogen; magnesium chloride; diisopropylamine; In tetrahydrofuran; ethyl acetate;

Reference yield: 70.0%

monomethyl oxalyl chloride (5781-53-3) + 5'-O-dimethoxytrityl-2'-amino-2'-deoxyuridine (174221-86-4) → 5'-O-(4,4'-dimethoxytrityl)-2'-methoxyoxalylamido-2'-deoxyuridine (177980-12-0)

Guidance literature:

With 1H-tetrazole; 2,4,6-trimethyl-pyridine; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile; for 0.25h; Ambient temperature;

DOI:10.1016/0040-4039(96)00537-0

upstream raw materials:

monomethyl oxalyl chloride

5'-O-dimethoxytrityl-2'-amino-2'-deoxyuridine

Dimethyl oxalate

5'-O-(4,4'-dimethoxytrityl)-2'-(trifluoroacetylamido)-2'-deoxyuridine

Downstream raw materials:

C₆₇H₆₇N₆O₁₉P

2'-[N,N-bis(2-methoxyoxalylaminoethyl)aminoethyl]-5'-O-(4,4'-dimethoxytrityl)aminooxalylamino-2'-deoxyuridine