2-pyridin-3-yl-succinic acid 1-benzyl ester trifluoroacetate

Base Information

• Chemical Name: 2-pyridin-3-yl-succinic acid 1-benzyl ester trifluoroacetate
• CAS No.: 1613317-48-8
• Molecular Formula: C₂HF₃O₂*C₁₆H₁₅NO₄
• Molecular Weight: 399.323
• Mol file: 1613317-48-8.mol

Synonyms:2-pyridin-3-yl-succinic acid 1-benzyl ester trifluoroacetate

Chemical Property of 2-pyridin-3-yl-succinic acid 1-benzyl ester trifluoroacetate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-pyridin-3-yl-succinic acid 1-benzyl ester trifluoroacetate

There total 4 articles about 2-pyridin-3-yl-succinic acid 1-benzyl ester trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-pyridin-3-yl-succinic acid 1-benzyl ester 4-tert-butyl ester (1613317-37-5) + trifluoroacetic acid (76-05-1) → 2-pyridin-3-yl-succinic acid 1-benzyl ester trifluoroacetate (1613317-48-8)

Guidance literature:

In dichloromethane; at 20 ℃; for 5h; Inert atmosphere;

Reference yield:

pyridyl-3-yl-acetic acid (501-81-5) → 2-pyridin-3-yl-succinic acid 1-benzyl ester trifluoroacetate (1613317-48-8)

Guidance literature:

Multi-step reaction with 3 steps

1: dmap; triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2: lithium hexamethyldisilazane / tetrahydrofuran / 3.5 h / -76 - 20 °C / Inert atmosphere

3: dichloromethane / 5 h / 20 °C / Inert atmosphere

With dmap; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

Reference yield:

pyridin-3-yl-acetic acid benzyl ester (170583-11-6) → 2-pyridin-3-yl-succinic acid 1-benzyl ester trifluoroacetate (1613317-48-8)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 3.5 h / -76 - 20 °C / Inert atmosphere

2: dichloromethane / 5 h / 20 °C / Inert atmosphere

With lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

upstream raw materials:

pyridyl-3-yl-acetic acid

pyridin-3-yl-acetic acid benzyl ester

benzyl chloroformate

2-pyridin-3-yl-succinic acid 1-benzyl ester 4-tert-butyl ester

Downstream raw materials:

N-[7-(4-cyclobutylthiazol-2-yl)naphthalen-2-yl]-2-pyridin-3-yl-succinamic acid benzyl ester