N-[7-(4-cyclobutylthiazol-2-yl)naphthalen-2-yl]-2-pyridin-3-yl-succinamic acid benzyl ester

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Chemical Name:N-[7-(4-cyclobutylthiazol-2-yl)naphthalen-2-yl]-2-pyridin-3-yl-succinamic acid benzyl ester
CAS No.:1613317-38-6
Molecular Formula:C₃₃H₂₉N₃O₃S
Molecular Weight:547.678
Hs Code.:

Synonyms:N-[7-(4-cyclobutylthiazol-2-yl)naphthalen-2-yl]-2-pyridin-3-yl-succinamic acid benzyl ester

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Chemical Property of N-[7-(4-cyclobutylthiazol-2-yl)naphthalen-2-yl]-2-pyridin-3-yl-succinamic acid benzyl ester

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Technology Process of N-[7-(4-cyclobutylthiazol-2-yl)naphthalen-2-yl]-2-pyridin-3-yl-succinamic acid benzyl ester

There total 6 articles about N-[7-(4-cyclobutylthiazol-2-yl)naphthalen-2-yl]-2-pyridin-3-yl-succinamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613317-48-8
2-pyridin-3-yl-succinic acid 1-benzyl ester trifluoroacetate

: 1613317-26-2
7-(4-cyclobutylthiazol-2-yl)naphthalen-2-ylamine

: 1613317-38-6
N-[7-(4-cyclobutylthiazol-2-yl)naphthalen-2-yl]-2-pyridin-3-yl-succinamic acid benzyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

Reference yield:

: 501-81-5
pyridyl-3-yl-acetic acid

: 1613317-38-6
N-[7-(4-cyclobutylthiazol-2-yl)naphthalen-2-yl]-2-pyridin-3-yl-succinamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2: lithium hexamethyldisilazane / tetrahydrofuran / 3.5 h / -76 - 20 °C / Inert atmosphere

3: dichloromethane / 5 h / 20 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With dmap; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 170583-11-6
pyridin-3-yl-acetic acid benzyl ester

: 1613317-38-6
N-[7-(4-cyclobutylthiazol-2-yl)naphthalen-2-yl]-2-pyridin-3-yl-succinamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 3.5 h / -76 - 20 °C / Inert atmosphere

2: dichloromethane / 5 h / 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;