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(3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetidinone

Base Information Edit
  • Chemical Name:(3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetidinone
  • CAS No.:149249-91-2
  • Molecular Formula:C22H27NO3Si
  • Molecular Weight:381.547
  • Hs Code.:
  • DSSTox Substance ID:DTXSID30440915
  • Nikkaji Number:J736.888G
  • Wikidata:Q72440460
  • Mol file:149249-91-2.mol
(3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetidinone

Synonyms:149249-91-2;(3R,4S)-1-BENZOYL-4-PHENYL-3-[(TRIETHYLSILYL)OXY]-2-AZETIDINONE;(3R,4S)-1-benzoyl-4-phenyl-3-triethylsilyloxyazetidin-2-one;2-Azetidinone, 1-benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-, (3R,4S)-;(3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)-oxy]-2-azetidinone;SCHEMBL4366611;DTXSID30440915;AMY16037;MFCD08273950;(3R,4S)-1-BENZOYL-4-PHENYL-3-(TRIETHYLSILYLOXY)AZETIDIN-2-ONE;AKOS016843304;AC-23878;AS-15777;CS-0130890;F13009;A808868;J-501260;(3R, 4S)-1-Benzoyl-4-phenyl-3-triethylsilyloxy-2-azetidinone;1-Benzoyl-3alpha-(triethylsiloxy)-4alpha-phenylazetidin-2-one;(3R,4S)-1-Benzoyl-4-phenyl-3-((triethylsilyl)oxy)azetidin-2-one

Suppliers and Price of (3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetidinone
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • (3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetidinone
  • 250mg
  • $ 605.00
  • TRC
  • (3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetidinone
  • 50mg
  • $ 160.00
  • Matrix Scientific
  • (3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)-oxy]-2-azetidinone 95+%
  • 1g
  • $ 1647.00
  • Matrix Scientific
  • (3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)-oxy]-2-azetidinone 95+%
  • 250mg
  • $ 742.00
  • Crysdot
  • (3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetidinone 95+%
  • 1g
  • $ 180.00
  • Crysdot
  • (3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetidinone 95+%
  • 250mg
  • $ 72.00
  • Crysdot
  • (3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetidinone 95+%
  • 5g
  • $ 540.00
  • Chemenu
  • (3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)-oxy]-2-azetidinone 95+%
  • 5g
  • $ 505.00
  • Biosynth Carbosynth
  • (3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetidinone
  • 250 mg
  • $ 100.00
  • Biosynth Carbosynth
  • (3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetidinone
  • 100 mg
  • $ 60.00
Total 80 raw suppliers
Chemical Property of (3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetidinone Edit
Chemical Property:
  • Vapor Pressure:0mmHg at 25°C 
  • Refractive Index:1.567 
  • Boiling Point:467.227 °C at 760 mmHg 
  • PKA:-4.66±0.60(Predicted) 
  • Flash Point:236.371 °C 
  • PSA:46.61000 
  • Density:1.13 g/cm3 
  • LogP:4.73860 
  • Storage Temp.:2-8°C 
  • Solubility.:Dichloromethane, Ether, Ethyl Acetate, Methanol 
  • Hydrogen Bond Donor Count:0
  • Hydrogen Bond Acceptor Count:3
  • Rotatable Bond Count:7
  • Exact Mass:381.17602026
  • Heavy Atom Count:27
  • Complexity:513
Purity/Quality:

99% *data from raw suppliers

(3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetidinone *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CC[Si](CC)(CC)OC1C(N(C1=O)C(=O)C2=CC=CC=C2)C3=CC=CC=C3
  • Isomeric SMILES:CC[Si](CC)(CC)O[C@@H]1[C@@H](N(C1=O)C(=O)C2=CC=CC=C2)C3=CC=CC=C3
  • Uses (3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetidinone is an intermedaite of 10-O-[(2R,3S)-3-(Benzoylamino)-2-hydroxy-3-phenylpropanoyl]-10-O-deacetylpaclitaxel (B207800), which is an impurity in the synthesis of Paclitaxel (P132500), an antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi''s sarcoma.
Technology Process of (3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetidinone

There total 12 articles about (3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
Multi-step reaction with 4 steps
1.1: 96 percent / triethylamine / tetrahydrofuran
2.1: 2.58 g / H2 / Pd/C / ethyl acetate / 20 h
3.1: trimethylsilyl chloride / diethyl ether / 1 h / 20 °C
3.2: 62 percent / tert-butylmagnesium chloride / diethyl ether / 3 h / 20 °C
4.1: 87 percent / triethylamine; 4-(dimethylamino)pyridine / CH2Cl2 / 20 h / 20 °C
With dmap; chloro-trimethyl-silane; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate;
DOI:10.1002/1099-0690(200105)2001:9<1761::AID-EJOC1761>3.0.CO;2-O
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