(S)-isopropyl 4-(2-(1-(2-fluoro-4-(methylsulfonyl)phenyl)pyrrolidin-3-yl)-2H-tetrazol-5-yl)piperidine-1-carboxylat

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Chemical Name:(S)-isopropyl 4-(2-(1-(2-fluoro-4-(methylsulfonyl)phenyl)pyrrolidin-3-yl)-2H-tetrazol-5-yl)piperidine-1-carboxylat
CAS No.:1054521-18-4
Molecular Formula:C₂₁H₂₉FN₆O₄S
Molecular Weight:480.563
Hs Code.:

Synonyms:(S)-isopropyl 4-(2-(1-(2-fluoro-4-(methylsulfonyl)phenyl)pyrrolidin-3-yl)-2H-tetrazol-5-yl)piperidine-1-carboxylat

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Chemical Property of (S)-isopropyl 4-(2-(1-(2-fluoro-4-(methylsulfonyl)phenyl)pyrrolidin-3-yl)-2H-tetrazol-5-yl)piperidine-1-carboxylat

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Technology Process of (S)-isopropyl 4-(2-(1-(2-fluoro-4-(methylsulfonyl)phenyl)pyrrolidin-3-yl)-2H-tetrazol-5-yl)piperidine-1-carboxylat

There total 5 articles about (S)-isopropyl 4-(2-(1-(2-fluoro-4-(methylsulfonyl)phenyl)pyrrolidin-3-yl)-2H-tetrazol-5-yl)piperidine-1-carboxylat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1054521-92-4
C₁₇H₂₃FN₆O₂S

: 108-23-6
isopropyl chloroformate

: 1054521-18-4
(S)-isopropyl 4-(2-(1-(2-fluoro-4-(methylsulfonyl)phenyl)pyrrolidin-3-yl)-2H-tetrazol-5-yl)piperidine-1-carboxylat

Guidance literature:: With triethylamine; In dichloromethane; toluene; for 0.5h;

Reference yield:

: 424792-57-4
1,2-difluoro-4-(methylsulfonyl)benzene

: 1054521-18-4
(S)-isopropyl 4-(2-(1-(2-fluoro-4-(methylsulfonyl)phenyl)pyrrolidin-3-yl)-2H-tetrazol-5-yl)piperidine-1-carboxylat

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 100 °C

2: pyridine / dichloromethane

3: caesium carbonate / 1-methyl-pyrrolidin-2-one / 0.08 h / 160 °C / Microwave irradiation

4: hydrogen; acetic acid; trifluoroacetic acid / platinum(IV) oxide / methanol / 72 h / 760.05 Torr

5: triethylamine / dichloromethane; toluene / 0.5 h

With pyridine; hydrogen; potassium carbonate; caesium carbonate; acetic acid; triethylamine; trifluoroacetic acid; platinum(IV) oxide; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1054521-30-0
(R)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyrrolidin-3-ol

: 1054521-18-4
(S)-isopropyl 4-(2-(1-(2-fluoro-4-(methylsulfonyl)phenyl)pyrrolidin-3-yl)-2H-tetrazol-5-yl)piperidine-1-carboxylat

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / dichloromethane

2: caesium carbonate / 1-methyl-pyrrolidin-2-one / 0.08 h / 160 °C / Microwave irradiation

3: hydrogen; acetic acid; trifluoroacetic acid / platinum(IV) oxide / methanol / 72 h / 760.05 Torr

4: triethylamine / dichloromethane; toluene / 0.5 h

With pyridine; hydrogen; caesium carbonate; acetic acid; triethylamine; trifluoroacetic acid; platinum(IV) oxide; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; toluene;