1-[4-(methylsulfonyl)phenyl]-2-(4-methoxy-3,5-dichlorophenyl)-4-trifluoromethyl-4-hydroxy-4,5-dihydro-1H-imidazole

Base Information

Chemical Name:1-[4-(methylsulfonyl)phenyl]-2-(4-methoxy-3,5-dichlorophenyl)-4-trifluoromethyl-4-hydroxy-4,5-dihydro-1H-imidazole
CAS No.:1027152-07-3
Molecular Formula:C₁₈H₁₅Cl₂F₃N₂O₄S
Molecular Weight:483.295
Hs Code.:

Synonyms:1-[4-(methylsulfonyl)phenyl]-2-(4-methoxy-3,5-dichlorophenyl)-4-trifluoromethyl-4-hydroxy-4,5-dihydro-1H-imidazole

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Chemical Property of 1-[4-(methylsulfonyl)phenyl]-2-(4-methoxy-3,5-dichlorophenyl)-4-trifluoromethyl-4-hydroxy-4,5-dihydro-1H-imidazole

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Technology Process of 1-[4-(methylsulfonyl)phenyl]-2-(4-methoxy-3,5-dichlorophenyl)-4-trifluoromethyl-4-hydroxy-4,5-dihydro-1H-imidazole

There total 6 articles about 1-[4-(methylsulfonyl)phenyl]-2-(4-methoxy-3,5-dichlorophenyl)-4-trifluoromethyl-4-hydroxy-4,5-dihydro-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 431-35-6
3-bromo-1,1,1-trifluoroacetone

: 3,5-Dichloro-N-(4-methanesulfonyl-phenyl)-4-methoxy-benzamidine

: 1027152-07-3
1-[4-(methylsulfonyl)phenyl]-2-(4-methoxy-3,5-dichlorophenyl)-4-trifluoromethyl-4-hydroxy-4,5-dihydro-1H-imidazole

Guidance literature:: With sodium hydrogencarbonate; In isopropyl alcohol; at 75 - 80 ℃; for 20h;
DOI:10.1021/jm9700225

Reference yield:

: 24295-27-0
methyl 3,5-dichloro-4-methoxybenzoate

: 1027152-07-3
1-[4-(methylsulfonyl)phenyl]-2-(4-methoxy-3,5-dichlorophenyl)-4-trifluoromethyl-4-hydroxy-4,5-dihydro-1H-imidazole

Guidance literature:: Multi-step reaction with 5 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Heating

2: oxalyl dichloride; dimethyl sulfoxide; triethylamine / 1.) CH₂Cl₂, -70 deg C, 1.5 h, 2.) CH₂Cl₂, -70 deg C - RT, 3 h

3: pyridine; hydroxylamine hydrochloride / 1.) RT, 15 min, 2.) toluene, reflux, 4 h

4: trimethylaluminum / 1.) toluene, a) 0 deg C - RT, b) RT, 3.5 h, 2.) toluene, 70 deg C - 75 deg C, 17 h

5: sodium hydrogencarbonate / isopropyl alcohol / 20 h / 75 - 80 °C

With pyridine; lithium aluminium tetrahydride; oxalyl dichloride; hydroxylamine hydrochloride; trimethylaluminum; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; isopropyl alcohol;
DOI:10.1021/jm9700225

Reference yield:

: 4892-23-3
3,5-dichloro-4-methoxybenzyl alcohol

: 1027152-07-3
1-[4-(methylsulfonyl)phenyl]-2-(4-methoxy-3,5-dichlorophenyl)-4-trifluoromethyl-4-hydroxy-4,5-dihydro-1H-imidazole

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / 1.) CH₂Cl₂, -70 deg C, 1.5 h, 2.) CH₂Cl₂, -70 deg C - RT, 3 h

2: pyridine; hydroxylamine hydrochloride / 1.) RT, 15 min, 2.) toluene, reflux, 4 h

3: trimethylaluminum / 1.) toluene, a) 0 deg C - RT, b) RT, 3.5 h, 2.) toluene, 70 deg C - 75 deg C, 17 h

4: sodium hydrogencarbonate / isopropyl alcohol / 20 h / 75 - 80 °C

With pyridine; oxalyl dichloride; hydroxylamine hydrochloride; trimethylaluminum; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; In isopropyl alcohol;
DOI:10.1021/jm9700225