3,5-Dichloro-4-methoxybenzoic acid

Base Information

• Chemical Name: 3,5-Dichloro-4-methoxybenzoic acid
• CAS No.: 41727-58-6
• Molecular Formula: C8H6Cl2O3
• Molecular Weight: 205.04
• Mol file: 41727-58-6.mol

Synonyms:3,5-Dichloro-4-methoxybenzaldehyde;

Chemical Property of 3,5-Dichloro-4-methoxybenzoic acid

Chemical Property:

• Melting Point: 199-200 °C
• Boiling Point: 328.9 °C at 760 mmHg
• Flash Point: 152.7 °C
• PSA: 46.53000
• Density: 1.474 g/cm³
• LogP: 2.70020
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

3,5-Dichloro-4-methoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-Dichloro-4-methoxybenzoic acid

There total 4 articles about 3,5-Dichloro-4-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3,5-dichloro-4-methoxybenzyl alcohol (4892-23-3) → 3,5-dichloro-4-methoxybenzaldehyde (41727-58-6)

Guidance literature:

With 4 A molecular sieve; pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1271/bbb.66.697

Reference yield: 24.0%

3,5-dichloro-4-hydroxybenzaldehyde (2314-36-5) + methyl iodide (74-88-4) → 3,5-dichloro-4-methoxybenzaldehyde (41727-58-6)

Guidance literature:

3,5-dichloro-4-hydroxybenzaldehyde; With potassium carbonate; In acetone; at 20 ℃; for 0.5h;

methyl iodide; In acetone; at 20 ℃; Reflux;

Reference yield:

methyl 3,5-dichloro-4-methoxybenzoate (24295-27-0) → 3,5-dichloro-4-methoxybenzaldehyde (41727-58-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / LiAlH₄ / diethyl ether / 1 h / 20 °C

2: 97 percent / PCC; molecular sieves 4 Angstroem / CH₂Cl₂ / 1 h / 20 °C

With lithium aluminium tetrahydride; 4 A molecular sieve; pyridinium chlorochromate; In diethyl ether; dichloromethane;

DOI:10.1271/bbb.66.697

upstream raw materials:

3,5-dichloro-4-methoxybenzyl alcohol

methyl 3,5-dichloro-4-methoxybenzoate

3,5-dichloro-4-hydroxybenzaldehyde

methyl iodide

Downstream raw materials:

3,5-dichloro-4-methyloxybenzonitrile

(+/-)-1-(3',5'-dichloro-4'-methoxyphenyl)-1-propanol

4-(3,5-dichloro-4-methoxybenzyl)-7-ethoxyisoquinolin-8-ol

1,3-dichloro-5-(2,2-dibromovinyl)-2-methoxybenzene

Refernces

• 1、 -. "Novel imidazole derivatives with anti-inflammatory activity". . . Retrieved 2008/06/13.
• 2、 -. "Compositions containing aromatic aldehydes and their use in treatments". . . Retrieved 2008/06/13.