(2S)-1-(2,4-difluorophenyl)-2-(1,1-dimethyl-1-silaethoxy)-propan-1-one

Base Information

• Chemical Name: (2S)-1-(2,4-difluorophenyl)-2-(1,1-dimethyl-1-silaethoxy)-propan-1-one
• CAS No.: 743449-15-2
• Molecular Formula: C₁₂H₁₆F₂O₂Si
• Molecular Weight: 258.34
• Mol file: 743449-15-2.mol

Synonyms:(2S)-1-(2,4-difluorophenyl)-2-(1,1-dimethyl-1-silaethoxy)-propan-1-one

Chemical Property of (2S)-1-(2,4-difluorophenyl)-2-(1,1-dimethyl-1-silaethoxy)-propan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-1-(2,4-difluorophenyl)-2-(1,1-dimethyl-1-silaethoxy)-propan-1-one

There total 1 articles about (2S)-1-(2,4-difluorophenyl)-2-(1,1-dimethyl-1-silaethoxy)-propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.8%

2,4-difluorobromobenzene (348-57-2) + (2S)-2-(1,1-dimethyl-1-silaethoxy)-1-(morpholin-4-yl)-propan-1-one (743449-14-1) → (2S)-1-(2,4-difluorophenyl)-2-(1,1-dimethyl-1-silaethoxy)-propan-1-one (743449-15-2)

Guidance literature:

2,4-difluorobromobenzene; With magnesium; In tetrahydrofuran; at 20 - 40 ℃;

(2S)-2-(1,1-dimethyl-1-silaethoxy)-1-(morpholin-4-yl)-propan-1-one; In tetrahydrofuran; at 20 ℃; for 4h;

DOI:10.1016/j.bmc.2004.02.014

Reference yield: 95.0%

Methyltriphenylphosphonium bromide (1779-49-3) + (2S)-1-(2,4-difluorophenyl)-2-(1,1-dimethyl-1-silaethoxy)-propan-1-one (743449-15-2) → 1-[(1S)-2-(2,4-difluorophenyl)-1-methylprop-2-enyloxy]-1,1-dimethyl-1-silaethane (743449-16-3)

Guidance literature:

Methyltriphenylphosphonium bromide; With potassium tert-butylate; In toluene; for 2h;

(2S)-1-(2,4-difluorophenyl)-2-(1,1-dimethyl-1-silaethoxy)-propan-1-one; In toluene; at 80 ℃; for 1h;

DOI:10.1016/j.bmc.2004.02.014

Reference yield:

(2S)-1-(2,4-difluorophenyl)-2-(1,1-dimethyl-1-silaethoxy)-propan-1-one (743449-15-2) → (2R,3S)-3-(5-{2-[4-(2-Butoxy-phenyl)-piperazin-1-yl]-ethyl}-tetrazol-1-yl)-2-(2,4-difluoro-phenyl)-1-[1,2,4]triazol-1-yl-butan-2-ol

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium tert-butoxide / toluene / 2 h

1.2: 95 percent / toluene / 1 h / 80 °C

2.1: 54.6 percent / formic acid / ethanol / 0.5 h / 20 °C

3.1: 60 percent / tert-butyl hydroperoxide; L-(+)-diethyl tartrate; titanium(IV) isopropoxide / CH₂Cl₂; toluene / 8 h / -20 - -10 °C

4.1: triethylamine / CH₂Cl₂ / 1 h / 5 °C

5.1: 2.04 g / NaH / dimethylformamide / 1.33 h / 0 - 55 °C

6.1: 15.7 percent / K₂CO₃ / 1-methyl-pyrrolidin-2-one; dimethylformamide / 10 h / 90 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; formic acid; diethyl (2R,3R)-tartrate; potassium tert-butylate; sodium hydride; potassium carbonate; triethylamine; In 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 3.1: Sharpless stereoselective epoxidation;

DOI:10.1016/j.bmc.2004.02.014

upstream raw materials:

2,4-difluorobromobenzene

(2S)-2-(1,1-dimethyl-1-silaethoxy)-1-(morpholin-4-yl)-propan-1-one

Downstream raw materials:

1-[(1S)-2-(2,4-difluorophenyl)-1-methylprop-2-enyloxy]-1,1-dimethyl-1-silaethane

(2S)-3-(2,4-Difluorophenyl)-3-buten-2-ol

(1S)-1-<(2R)-2-(2,4-difluorophenyl)-2-oxiranyl>ethanol

1-(((2R,3R)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole