1-[(1S)-2-(2,4-difluorophenyl)-1-methylprop-2-enyloxy]-1,1-dimethyl-1-silaethane

Base Information

Chemical Name:1-[(1S)-2-(2,4-difluorophenyl)-1-methylprop-2-enyloxy]-1,1-dimethyl-1-silaethane
CAS No.:743449-16-3
Molecular Formula:C₁₃H₁₈F₂OSi
Molecular Weight:256.368
Hs Code.:

Synonyms:1-[(1S)-2-(2,4-difluorophenyl)-1-methylprop-2-enyloxy]-1,1-dimethyl-1-silaethane

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Chemical Property of 1-[(1S)-2-(2,4-difluorophenyl)-1-methylprop-2-enyloxy]-1,1-dimethyl-1-silaethane

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Technology Process of 1-[(1S)-2-(2,4-difluorophenyl)-1-methylprop-2-enyloxy]-1,1-dimethyl-1-silaethane

There total 2 articles about 1-[(1S)-2-(2,4-difluorophenyl)-1-methylprop-2-enyloxy]-1,1-dimethyl-1-silaethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1779-49-3
Methyltriphenylphosphonium bromide

: 743449-15-2
(2S)-1-(2,4-difluorophenyl)-2-(1,1-dimethyl-1-silaethoxy)-propan-1-one

: 743449-16-3
1-[(1S)-2-(2,4-difluorophenyl)-1-methylprop-2-enyloxy]-1,1-dimethyl-1-silaethane

Guidance literature:: Methyltriphenylphosphonium bromide; With potassium tert-butylate; In toluene; for 2h;

(2S)-1-(2,4-difluorophenyl)-2-(1,1-dimethyl-1-silaethoxy)-propan-1-one; In toluene; at 80 ℃; for 1h;
DOI:10.1016/j.bmc.2004.02.014

Reference yield:

: 743449-14-1
(2S)-2-(1,1-dimethyl-1-silaethoxy)-1-(morpholin-4-yl)-propan-1-one

: 743449-16-3
1-[(1S)-2-(2,4-difluorophenyl)-1-methylprop-2-enyloxy]-1,1-dimethyl-1-silaethane

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium / tetrahydrofuran / 20 - 40 °C

1.2: 84.8 percent / tetrahydrofuran / 4 h / 20 °C

2.1: potassium tert-butoxide / toluene / 2 h

2.2: 95 percent / toluene / 1 h / 80 °C

With potassium tert-butylate; magnesium; In tetrahydrofuran; toluene;
DOI:10.1016/j.bmc.2004.02.014