methyl 3-amino-6-(4-(methylsulfonyl)phenyl)pyrazine-2-carboxylate

Base Information

• Chemical Name: methyl 3-amino-6-(4-(methylsulfonyl)phenyl)pyrazine-2-carboxylate
• CAS No.: 1232423-27-6
• Molecular Formula: C₁₃H₁₃N₃O₄S
• Molecular Weight: 307.33
• Mol file: 1232423-27-6.mol

Synonyms:methyl 3-amino-6-(4-(methylsulfonyl)phenyl)pyrazine-2-carboxylate

Chemical Property of methyl 3-amino-6-(4-(methylsulfonyl)phenyl)pyrazine-2-carboxylate

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

3-Amino-6-(4-methanesulfonylphenyl)pyrazine-2-carboxylic acid methyl ester 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 3-amino-6-(4-(methylsulfonyl)phenyl)pyrazine-2-carboxylate

There total 3 articles about methyl 3-amino-6-(4-(methylsulfonyl)phenyl)pyrazine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.6%

methyl 3-amino-6-bromopyrazine-2-carboxylate (6966-01-4) + (4,4,5,5-tetramethyl-2-[4-(methylsulfonyl)phenyl])-1,3,2-dioxaborolane (603143-27-7) → methyl 3-amino-6-(4-(methylsulfonyl)phenyl)pyrazine-2-carboxylate (1232423-27-6)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride; In methanol; at 110 ℃; for 1h; Microwave irradiation; Inert atmosphere;

Reference yield: 9.3%

methyl 3-amino-6-bromopyrazine-2-carboxylate (6966-01-4) + 4-methanesulphonylphenylboronic acid (149104-88-1) → methyl 3-amino-6-(4-(methylsulfonyl)phenyl)pyrazine-2-carboxylate (1232423-27-6)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride; In methanol; at 100 ℃; for 1h; Microwave irradiation;

Reference yield:

(4,4,5,5-tetramethyl-2-[4-(methylsulfonyl)phenyl])-1,3,2-dioxaborolane (603143-27-7) + 3-amino-6-bromo-N-phenyl-pyrazine-2-carboxamide (36204-92-9) → methyl 3-amino-6-(4-(methylsulfonyl)phenyl)pyrazine-2-carboxylate (1232423-27-6)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In water; N,N-dimethyl-formamide; at 110 ℃; for 1h; Inert atmosphere; Microwave irradiation;

DOI:10.1016/j.nucmedbio.2017.01.002

upstream raw materials:

(4,4,5,5-tetramethyl-2-[4-(methylsulfonyl)phenyl])-1,3,2-dioxaborolane

3-amino-6-bromo-N-phenyl-pyrazine-2-carboxamide

methyl 3-amino-6-bromopyrazine-2-carboxylate

4-methanesulphonylphenylboronic acid

Downstream raw materials:

3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide

3-amino-6-(4-(methylsulfonyl)phenyl)pyrazine-2-carboxylic acid

3-hydroxy-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide

3-bromo-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide