(R)-1-Boc-3-(aminomethyl)piperidine

Base Information

Chemical Name:(R)-1-Boc-3-(aminomethyl)piperidine
CAS No.:140645-23-4
Molecular Formula:C11H22N2O2
Molecular Weight:214.308
Hs Code.:2933399090
European Community (EC) Number:674-634-7
DSSTox Substance ID:DTXSID00363586
Wikidata:Q72448240
Mol file:140645-23-4.mol

Synonyms:140645-23-4;(R)-1-Boc-3-(aminomethyl)piperidine;(r)-n-boc-3-aminomethylpiperidine;(r)-tert-butyl 3-(aminomethyl)piperidine-1-carboxylate;tert-butyl (3R)-3-(aminomethyl)piperidine-1-carboxylate;(R)-1-N-Boc-3-(aminomethyl)piperidine;(r)-3-(aminomethyl)-1-n-boc-piperidine;(R)-3-Aminomethyl-1-N-Boc-piperidine;(r)-1-boc-3-(aminomethyl) piperidine;MFCD03839876;(r)-3-aminomethyl-piperidine-1-carboxylic acid tert-butyl ester;(3R)-1-Boc-3-(aminomethyl)piperidine;(r)-3-aminomethyl-1-boc-piperidine;1-PIPERIDINECARBOXYLIC ACID, 3-(AMINOMETHYL)-, 1,1-DIMETHYLETHYL ESTER, (3R)-;(3R)-3-Aminomethyl-N-tert-butoxycarbonylpiperidine;SCHEMBL1192567;AMY4374;DTXSID00363586;(r)-1-boc-3-aminomethylpiperidine;CS-B0445;AKOS005258696;AKOS015897899;(r)-1-n-boc-piperidine-3-methylamine;AC-1458;A3035;(R)-1-Boc-3-(aminomethyl)piperidine, 97%;(r)-3-(aminomethyl)piperidine, n1-boc protected;EN300-5248015;(R)-1-Boc-3-(aminomethyl)piperidine, AldrichCPR;Q-102965;(3R)-3-(aminomethyl)-1-(t-butoxycarbonyl)piperidine;(3R)-3-aminomethyl-1-(tert-butoxycarbonyl)piperidine;(3R)-3-aminomethyl-1-(tert-butoxycarbonyl)-piperidine;(r)-tert-butyl-3-(aminomethyl)piperidine-1-carboxylate;(r)3-aminomethyl-piperidine-1-carboxylic acid tert-butyl ester;3(r)-aminomethyl-piperidine-1-carboxylic acid tert-butyl ester;1,1-DIMETHYL (3R)-3-(AMINOMETHYL)-1-PIPERIDINECARBOXYLATE;1,1-dimethylethyl (3R)-3-(aminomethyl)-1-piperidinecarboxylate

Suppliers and Price of (R)-1-Boc-3-(aminomethyl)piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-tert-Butyl3-(Aminomethyl)piperidine-1-carboxylate
100mg
$ 75.00

Synthonix
(R)-1-Boc-3-aminomethyl-piperidine 95+%
1g
$ 60.00

Synthonix
(R)-1-Boc-3-aminomethyl-piperidine 95+%
5g
$ 170.00

SynQuest Laboratories
(3R)-3-(Aminomethyl)piperidine, N1-Boc protected
5 g
$ 247.00

SynQuest Laboratories
(3R)-3-(Aminomethyl)piperidine, N1-Boc protected
250 mg
$ 24.00

SynQuest Laboratories
(3R)-3-(Aminomethyl)piperidine, N1-Boc protected
1 g
$ 82.00

Sigma-Aldrich
(R)-1-Boc-3-(aminomethyl)piperidine 97%
500mg
$ 90.50

Sigma-Aldrich
(R)-1-Boc-3-(aminomethyl)piperidine Aldrich
250mg
$ 77.50

Matrix Scientific
(R)-1-N-Boc-3-(aminomethyl)piperidine 98%
500mg
$ 75.00

Matrix Scientific
(R)-1-N-Boc-3-(aminomethyl)piperidine 98%
1g
$ 99.00

Total 53 raw suppliers

Chemical Property of (R)-1-Boc-3-(aminomethyl)piperidine

Chemical Property:

Vapor Pressure:0.001mmHg at 25°C
Refractive Index:n20/D 1.473
Boiling Point:299.4 °C at 760 mmHg
PKA:10.12±0.29(Predicted)
Flash Point:134.9 °C
PSA：55.56000
Density:1.023 g/cm³
LogP:2.23040
Storage Temp.:2-8°C
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:214.168127949
Heavy Atom Count:15
Complexity:223

Purity/Quality:

99%, ^*data from raw suppliers

(R)-tert-Butyl3-(Aminomethyl)piperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi,Xn,N
Statements: 22-50-36/37/38
Safety Statements: 26-61

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCCC(C1)CN
Isomeric SMILES:CC(C)(C)OC(=O)N1CCC[C@@H](C1)CN

Technology Process of (R)-1-Boc-3-(aminomethyl)piperidine

There total 9 articles about (R)-1-Boc-3-(aminomethyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 140645-22-3
(3S)-3-azidomethyl-1-(tert-butoxycarbonyl)-piperidine

: 140645-23-4
1,1-dimethylethyl (3R)-3-(aminomethyl)-1-piperidinecarboxylate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 1.5h; under 7500.6 Torr; Ambient temperature;
DOI:10.1021/jm00049a008

Reference yield:

: 140695-84-7
tert-butyl (3S)-3-(hydroxymethyl)piperidine-1-carboxylate

: 140645-23-4
1,1-dimethylethyl (3R)-3-(aminomethyl)-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: NEt₃ / CH₂Cl₂ / 1.5 h / 0 °C

2: sodium azide / dimethylformamide / 24 h / 50 °C

3: H₂ / Pd/C / ethanol / 1.5 h / 7500.6 Torr / Ambient temperature

With sodium azide; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00049a008

Reference yield:

: 364356-44-5
(S)-<<(methylsulfonyl)oxy>methyl>piperidine-1-carboxylic acid tert-butyl ester

: 140645-23-4
1,1-dimethylethyl (3R)-3-(aminomethyl)-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / dimethylformamide / 24 h / 50 °C

2: H₂ / Pd/C / ethanol / 1.5 h / 7500.6 Torr / Ambient temperature

With sodium azide; hydrogen; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00049a008