140645-22-3

Usage

Uses

Used in Organic Synthesis:
(S)-Tert-Butyl 3-(azidomethyl)piperidine-1-carboxylate is used as a synthetic intermediate for the preparation of various piperidine derivatives. Its azide functional group allows for click chemistry reactions, which are valuable in creating complex molecular structures with high efficiency and selectivity.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (S)-Tert-Butyl 3-(azidomethyl)piperidine-1-carboxylate serves as a building block for the synthesis of biologically active compounds. Its structural features may contribute to potential pharmacological applications, making it a valuable tool for drug discovery and development.
Used in Chemical Biology Research:
Additionally, (S)-Tert-Butyl 3-(azidomethyl)piperidine-1-carboxylate can be employed as a research tool in chemical biology. Its unique properties and reactivity make it suitable for exploring new chemical reactions and understanding the interactions between molecules at a fundamental level.
Overall, (S)-Tert-Butyl 3-(azidomethyl)piperidine-1-carboxylate has a wide range of applications across different industries, including organic synthesis, medicinal chemistry, and chemical biology research, due to its versatile chemical properties and potential for creating novel compounds with biological activity.

Upstream product

• 364356-44-5 (S)-<<(methylsulfonyl)oxy>methyl>piperidine-1-carboxylic acid tert-butyl ester 
• 4606-65-9 (S)-(hydroxymethyl)piperidine 
• 191092-08-7 tert-butyl (3S)-3-[[(4-methylbenzenesulfonyl)oxy]methyl]piperidine-1-carboxylate 
• 191599-51-6 ethyl (S)-1-[(tert-butoxy)carbonyl]piperidine-3-carboxylate 
• 37675-18-6 (S)-(+)-nipecotic acid ethyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 140695-84-7 tert-butyl (3S)-3-(hydroxymethyl)piperidine-1-carboxylate 

Downstream Products

• 140645-23-4 1,1-dimethylethyl (3R)-3-(aminomethyl)-1-piperidinecarboxylate 
• 879275-35-1 (R)-<<(benzyloxycarbonyl)amino>methyl>piperidine-1-carboxylic acid tert-butyl ester 
• 879396-20-0 (S)-1-Piperidin-3-ylmethyl-carbamic acid benzyl ester 

Relevant academic research and scientific papers

INDOLE DERIVATIVES AND USES THEREOF FOR TREATING A CANCER

The present invention relates to indole derivatives of formula (I') as CK2 inhibitor and pharmaceutical compositions comprising the same. The present invention further relates to the use of such compounds of formula (I) for use for preventing and/or treating a cancer.

Novel Triazolopyrazine Derivatives and Use Thereof

The present invention relates to novel triazolopyrazine derivatives or a pharmaceutically acceptable salt, and a pharmaceutical composition for inhibiting c-Met tyrosine kinase activity and a pharmaceutical composition for preventing or treating hyperproliferative disorders, containing the same as active ingredients. The present invention effectively inhibits c-Met tyrosine kinase activity, thereby being able to be useful as a drug for various hyperproliferative disorders such as cancers, psoriasis, rheumatoid arthritis, diabetic retinitis, etc. related to excessive cell proliferation and growth by abnormal kinase activation.

NOVEL TRIAZOLOPYRAZINE DERIVATIVE AND USE THEREOF

The present invention relates to a novel triazolopyrazine derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same as an active ingredient for preventing or treating hyper proliferative disorder. The present invention can be useful as a therapeutic agent for various hyper proliferative disorders associated with excessive cell proliferation and growth caused by abnormal kinase activity, such as cancer, psoriasis, rheumatoid arthritis, and diabetic retinopathy, by efficiently inhibiting c-Met tyrosine kinase activity.

NOVEL AMIDE DERIVATIVES

This invention relates to compounds which are represented by the general formula [I] ???[in which A stands for a group of the following formula [ao] or [b0] ???Ar1, Ar2 and Ar3 stand for optionally substituted phenyl; k stands for 0 or 1; m, n and s stand for 0, 1 or 2; R1 stands for hydrogen or optionally substituted lower alkyl; R2, R3, R4 and R5 either stand for hydrogen or optionally substituted lower alkyl, or R2 and R3, or R4 and R5 together stand for trimethylene and the like; R60 stands for hydrogen, alkyl, or the like; R61and R71 either stand for alkyl and the like, or together stand for trimethylene and the like; X stands for carbonyl or methylene; Y stands for nitrogen or methine; and Q- stands for anion], and the like. The compounds of the invention exhibit selective antagonism to muscarinic M3 receptors, and therefore are useful as safe and effective agents showing little side effect, for treating diseases of the respiratory, urinary and digestive systems.

Design and synthesis of potent and highly selective thrombin inhibitors

Thrombin, a serine protease, plays a central role in the initiation and propagation of thrombotic events. An extensive search for new thrombin inhibitors was performed, using an unconventional approach. Screening of small basic molecules for binding in th