10-deacetoxy-10-(2-hydroxyethyl)-7-O-13-O-bis-triethylsilylbaccatin III

Base Information

Chemical Name:10-deacetoxy-10-(2-hydroxyethyl)-7-O-13-O-bis-triethylsilylbaccatin III
CAS No.:325735-53-3
Molecular Formula:C₄₃H₆₈O₁₀Si₂
Molecular Weight:801.178
Hs Code.:

Synonyms:10-deacetoxy-10-(2-hydroxyethyl)-7-O-13-O-bis-triethylsilylbaccatin III

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Chemical Property of 10-deacetoxy-10-(2-hydroxyethyl)-7-O-13-O-bis-triethylsilylbaccatin III

Chemical Property:

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Technology Process of 10-deacetoxy-10-(2-hydroxyethyl)-7-O-13-O-bis-triethylsilylbaccatin III

There total 9 articles about 10-deacetoxy-10-(2-hydroxyethyl)-7-O-13-O-bis-triethylsilylbaccatin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 325735-52-2
10-deacetoxy-10-formylmethyl-7-O-13-O-bis-triethylsilylbaccatin III

: 325735-53-3
10-deacetoxy-10-(2-hydroxyethyl)-7-O-13-O-bis-triethylsilylbaccatin III

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 ℃; for 2h;
DOI:10.3987/COM-00-9051

Reference yield:

: 204764-74-9
10-deacetoxy-10-hydroxypropyl-7-O-triethylsilylbaccatin III

: 325735-53-3
10-deacetoxy-10-(2-hydroxyethyl)-7-O-13-O-bis-triethylsilylbaccatin III

Guidance literature:: Multi-step reaction with 5 steps

1.1: 73 percent / n-Bu₃P / tetrahydrofuran / 2 h / 20 °C

2.1: 81 percent / m-CPBA / tetrahydrofuran / 3 h / 20 °C

3.1: imidazole / dimethylformamide / 2 h / 20 °C

4.1: OsO₄; NMO / tetrahydrofuran; H₂O / 15 h / 20 °C

4.2: NaIO₄ / tetrahydrofuran; methanol; H₂O / 6 h / 20 °C

5.1: 96 percent / NaBH₄ / methanol / 2 h / 0 °C

With 1H-imidazole; sodium tetrahydroborate; osmium(VIII) oxide; N-methyl-2-indolinone; tributylphosphine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.3987/COM-00-9051

Reference yield:

: 994-30-9
triethylsilyl chloride

: 325735-53-3
10-deacetoxy-10-(2-hydroxyethyl)-7-O-13-O-bis-triethylsilylbaccatin III

Guidance literature:: Multi-step reaction with 3 steps

1.1: imidazole / dimethylformamide / 2 h / 20 °C

2.1: OsO₄; NMO / tetrahydrofuran; H₂O / 15 h / 20 °C

2.2: NaIO₄ / tetrahydrofuran; methanol; H₂O / 6 h / 20 °C

3.1: 96 percent / NaBH₄ / methanol / 2 h / 0 °C

With 1H-imidazole; sodium tetrahydroborate; osmium(VIII) oxide; N-methyl-2-indolinone; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.3987/COM-00-9051