(1R,2R,4S)-4-(methanesulphonyl(methyl)amino)-2-((R)-1-phenyl-ethylcarbamoyl)-cyclopentanecarboxylic acid methyl ester

Base Information

Chemical Name:(1R,2R,4S)-4-(methanesulphonyl(methyl)amino)-2-((R)-1-phenyl-ethylcarbamoyl)-cyclopentanecarboxylic acid methyl ester
CAS No.:1067648-66-1
Molecular Formula:C₁₈H₂₆N₂O₅S
Molecular Weight:382.481
Hs Code.:

Synonyms:(1R,2R,4S)-4-(methanesulphonyl(methyl)amino)-2-((R)-1-phenyl-ethylcarbamoyl)-cyclopentanecarboxylic acid methyl ester

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Chemical Property of (1R,2R,4S)-4-(methanesulphonyl(methyl)amino)-2-((R)-1-phenyl-ethylcarbamoyl)-cyclopentanecarboxylic acid methyl ester

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Technology Process of (1R,2R,4S)-4-(methanesulphonyl(methyl)amino)-2-((R)-1-phenyl-ethylcarbamoyl)-cyclopentanecarboxylic acid methyl ester

There total 8 articles about (1R,2R,4S)-4-(methanesulphonyl(methyl)amino)-2-((R)-1-phenyl-ethylcarbamoyl)-cyclopentanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1067648-65-0
(1R,2R,4R)-4-methanesulphonyl(methyl)amino-cyclopentane-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 1067648-66-1
(1R,2R,4S)-4-(methanesulphonyl(methyl)amino)-2-((R)-1-phenyl-ethylcarbamoyl)-cyclopentanecarboxylic acid methyl ester

Guidance literature:: (1R,2R,4R)-4-methanesulphonyl(methyl)amino-cyclopentane-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester; With triethylsilane; trifluoroacetic acid; In dichloromethane; for 1h;

(R)-1-phenyl-ethyl-amine; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 0 ℃; for 2.5h;

Reference yield:

: 1067652-68-9
C₁₀H₁₇NO₆S

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 1067648-66-1
(1R,2R,4S)-4-(methanesulphonyl(methyl)amino)-2-((R)-1-phenyl-ethylcarbamoyl)-cyclopentanecarboxylic acid methyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 0 ℃; for 2.5h;

Reference yield:

: (1S,4S,5S)-3-oxo-2-oxa-bicyclo[2.2.1]heptane-5-carboxylic acid

: 1067648-66-1
(1R,2R,4S)-4-(methanesulphonyl(methyl)amino)-2-((R)-1-phenyl-ethylcarbamoyl)-cyclopentanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: dichloromethane / 23 h

2.1: potassium carbonate / 0.5 h / 0 °C

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.17 h / 0 °C

3.2: 2.33 h / 0 °C

4.1: water; triphenylphosphine / methanol / 23 h

5.1: pyridine / dichloromethane / 0 - 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 1.33 h

7.1: triethylsilane; trifluoroacetic acid / dichloromethane / 1 h

7.2: 2.5 h / 0 °C

With pyridine; triethylsilane; di-isopropyl azodicarboxylate; water; sodium hydride; potassium carbonate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;