5-bromo-2-nitrophenyl phenyl ether

Base Information

• Chemical Name: 5-bromo-2-nitrophenyl phenyl ether
• CAS No.: 853996-42-6
• Molecular Formula: C₁₂H₈BrNO₃
• Molecular Weight: 294.104
• Mol file: 853996-42-6.mol

Synonyms:5-bromo-2-nitrophenyl phenyl ether

Chemical Property of 5-bromo-2-nitrophenyl phenyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 5-bromo-2-nitrophenyl phenyl ether

There total 2 articles about 5-bromo-2-nitrophenyl phenyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-bromo-2-fluoronitrobenzene (321-23-3) + phenol (108-95-2,27073-41-2) → 5-bromo-2-nitrophenyl phenyl ether (853996-42-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 12h; Cooling with ice;

Reference yield:

2,4-dibromonitrobenzene (51686-78-3) + sodium phenoxide (139-02-6) → 5-bromo-2-nitrophenyl phenyl ether (853996-42-6)

Guidance literature:

With copper; phenol; at 150 ℃;

DOI:10.1039/jr9300001202

Reference yield: 94.0%

5-bromo-2-nitrophenyl phenyl ether (853996-42-6) + tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate (375853-82-0,286961-14-6) → tert-butyl 4-(4-nitro-3-phenoxyphenyl)-3,6-dihydro-2H-pyridine-1-carboxylate

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; cesium fluoride; In N,N-dimethyl-formamide; at 85 ℃; for 7h; Inert atmosphere;

upstream raw materials:

2,4-dibromonitrobenzene

sodium phenoxide

4-bromo-2-fluoronitrobenzene

phenol

Downstream raw materials:

2-amino-5-bromodiphenyl ether

(5-bromo-2-nitro-phenyl)-(4-bromo-phenyl)-ether

(4,5-dibromo-2-nitro-phenyl)-(2,4-dibromo-phenyl)-ether

4-bromo-2-(4-bromo-phenoxy)-aniline