(S)-1-N-Boc-2-ethylpiperazine

Base Information

• Chemical Name: (S)-1-N-Boc-2-ethylpiperazine
• CAS No.: 325145-35-5
• Molecular Formula: C11H22N2O2
• Molecular Weight: 214.308
• Hs Code.: 2933599090
• Mol file: 325145-35-5.mol

Synonyms:(2S)-2-Ethyl-1-piperazinecarboxylicacid 1,1-dimethylethyl ester;(S)-2-Ethylpiperazine-1-carboxylic acidtert-butyl ester;1-(tert-Butoxycarbonyl)-2(S)-ethylpiperazine;tert-butyl (2S)-2-ethylpiperazine-1-carboxylate;

Chemical Property of (S)-1-N-Boc-2-ethylpiperazine

Chemical Property:

• Vapor Pressure: 0.0026mmHg at 25°C
• Refractive Index: 1.457
• Boiling Point: 286.7 °C at 760 mmHg
• PKA: 8.49±0.40(Predicted)
• Flash Point: 127.2 °C
• PSA: 41.57000
• Density: 0.981 g/cm³
• LogP: 1.87200
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

(S)-1-BOC-2-Ethylpiperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of (S)-1-N-Boc-2-ethylpiperazine

There total 7 articles about (S)-1-N-Boc-2-ethylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S)-2-ethyl-4-(phenylmethyl)-1-piperazinecarboxylic acid, 1,1-dimethylethyl ester (502482-44-2) → (S)-2-ethylpiperazine-1-carboxylic acid tert-butyl ester (325145-35-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 16h;

DOI:10.1021/jm9508090

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (S)-2-ethylpiperazine-1-carboxylic acid tert-butyl ester (325145-35-5)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 2 h

2: H₂ / 10percent Pd/C / methanol / 16 h

With hydrogen; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1021/jm9508090

Reference yield:

(3S)-1-benzyl-3-ethylpiperazine (324750-04-1,347195-55-5) → (S)-2-ethylpiperazine-1-carboxylic acid tert-butyl ester (325145-35-5)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 2 h

2: H₂ / 10percent Pd/C / methanol / 16 h

With hydrogen; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1021/jm9508090

upstream raw materials:

(2S)-2-ethyl-4-(phenylmethyl)-1-piperazinecarboxylic acid, 1,1-dimethylethyl ester

di-tert-butyl dicarbonate

(3S)-1-benzyl-3-ethylpiperazine

(3S)-3-ethyl-1-(phenylmethyl)-2,5-piperazinedione

Refernces

• 1、 -. "PHENOXYACETIC ACID DERIVATIVES USEFUL FOR TREATING RESPIRATORY DISEASES". Page/Page column 67. . Retrieved 2008/06/13.
• 2、 -. "Benzofurylpiperazine serotonin agonists". . . Retrieved 2008/06/13.