(2R,4R)-N-Boc-4-hydroxy-2-methylpyrrolidine

Base Information

Chemical Name:(2R,4R)-N-Boc-4-hydroxy-2-methylpyrrolidine
CAS No.:114676-93-6
Molecular Formula:C10H19NO3
Molecular Weight:201.266
Hs Code.:2933998090
European Community (EC) Number:871-734-4
Nikkaji Number:J998.442I
Mol file:114676-93-6.mol

Synonyms:114676-93-6;(2R,4R)-N-BOC-4-HYDROXY-2-METHYLPYRROLIDINE;tert-butyl (2R,4R)-4-hydroxy-2-methylpyrrolidine-1-carboxylate;(2R,4R)-TERT-BUTYL 4-HYDROXY-2-METHYLPYRROLIDINE-1-CARBOXYLATE;(2R, 4R)-4-Hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester;1-Pyrrolidinecarboxylic acid, 4-hydroxy-2-methyl-, 1,1-dimethylethyl ester, (2R,4R)-;(2R,4R)-1-Boc-4-Hydroxy-2-methylpyrrolidine;MFCD11109735;SCHEMBL2202251;BXZADLGAYWRZCR-HTQZYQBOSA-N;AMY35431;AKOS015840329;GS-5540;AC-29642;CS-0048636;P11072;EN300-3490199;(2R,4R)-1-(t-butoxycarbonyl)-4-hydroxy-2-methylpyrrolidine;(2R,4R)-1-(tert-butoxycarbonyl)-4-hydroxy-2-methylpyrrolidine;tert-Butyl (2R,4R)-4-hydroxy-2-methyl-1-pyrrolidinecarboxylate

Suppliers and Price of (2R,4R)-N-Boc-4-hydroxy-2-methylpyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
tert-butyl(2R,4R)-4-hydroxy-2-methylpyrrolidine-1-carboxylate
50mg
$ 155.00

J&W Pharmlab
(2R,4R)-4-Hydroxy-2-methyl-pyrrolidine-1-carboxylicacidtert-butylester 96%
250mg
$ 160.00

J&W Pharmlab
(2R,4R)-4-Hydroxy-2-methyl-pyrrolidine-1-carboxylicacidtert-butylester 96%
100mg
$ 130.00

J&W Pharmlab
(2R,4R)-4-Hydroxy-2-methyl-pyrrolidine-1-carboxylicacidtert-butylester 96%
50mg
$ 115.00

J&W Pharmlab
(2R,4R)-4-Hydroxy-2-methyl-pyrrolidine-1-carboxylicacidtert-butylester 96%
500mg
$ 220.00

J&W Pharmlab
(2R,4R)-4-Hydroxy-2-methyl-pyrrolidine-1-carboxylicacidtert-butylester 96%
1g
$ 339.00

J&W Pharmlab
(2R,4R)-4-Hydroxy-2-methyl-pyrrolidine-1-carboxylicacidtert-butylester 96%
5g
$ 1018.00

Crysdot
(2R,4R)-tert-Butyl4-hydroxy-2-methylpyrrolidine-1-carboxylate 95+%
5g
$ 1042.00

Crysdot
(2R,4R)-tert-Butyl4-hydroxy-2-methylpyrrolidine-1-carboxylate 95+%
25g
$ 3472.00

Crysdot
(2R,4R)-tert-Butyl4-hydroxy-2-methylpyrrolidine-1-carboxylate 95+%
10g
$ 1736.00

Total 28 raw suppliers

Chemical Property of (2R,4R)-N-Boc-4-hydroxy-2-methylpyrrolidine

Chemical Property:

Refractive Index:1.489
Boiling Point:282.5 °C at 760 mmHg
Flash Point:124.7 °C
PSA：49.77000
Density:1.094 g/cm³
LogP:1.31450
Storage Temp.:2-8°C
XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:201.13649347
Heavy Atom Count:14
Complexity:222

Purity/Quality:

97% ^*data from raw suppliers

tert-butyl(2R,4R)-4-hydroxy-2-methylpyrrolidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CC(CN1C(=O)OC(C)(C)C)O
Isomeric SMILES:C[C@@H]1C[C@H](CN1C(=O)OC(C)(C)C)O

Technology Process of (2R,4R)-N-Boc-4-hydroxy-2-methylpyrrolidine

There total 9 articles about (2R,4R)-N-Boc-4-hydroxy-2-methylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 132945-96-1
tert-butyl (2R,4R)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-methylpyrrolidine-1-carboxylate

: 114676-93-6,2299231-07-3
(2R,4R)-tert-butyl 4-hydroxy-2-methylpyrrolidine-1-carboxylate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 - 25 ℃;
DOI:10.1016/j.ejmech.2019.02.077

Reference yield:

: 109431-87-0,83220-73-9
(R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate

: 77-78-1
dimethyl sulfate

: 114676-93-6,2299231-07-3
(2R,4R)-tert-butyl 4-hydroxy-2-methylpyrrolidine-1-carboxylate

: 114676-61-8,2299231-07-3
tert-butyl (2S,4R)-4-hydroxyl-2-methylpyrrolidine-1-carboxylate

Guidance literature:: With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; Yield given. Yields of byproduct given. Title compound not separated from byproducts; 1.) -78 to -46 deg C, 2 h, 2.) -78 deg C;
DOI:10.1039/a804211j

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 114676-93-6,2299231-07-3
(2R,4R)-tert-butyl 4-hydroxy-2-methylpyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / 1,4-dioxane; water / 0 - 20 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

3: lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: triethylamine / dichloromethane / 0 °C / Inert atmosphere

5: lithium triethylborohydride / tetrahydrofuran / 2 h / 20 °C / Cooling with ice; Inert atmosphere

6: tetrabutyl ammonium fluoride / tetrahydrofuran / Inert atmosphere

With 1H-imidazole; lithium borohydride; tetrabutyl ammonium fluoride; lithium triethylborohydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ml4002425