(-)-(R)-phenylpropiolic acid 1-phenylethylamine

Base Information

• Chemical Name: (-)-(R)-phenylpropiolic acid 1-phenylethylamine
• CAS No.: 86980-83-8
• Molecular Formula: C₁₇H₁₅NO
• Molecular Weight: 249.312
• Mol file: 86980-83-8.mol

Synonyms:(-)-(R)-phenylpropiolic acid 1-phenylethylamine

Chemical Property of (-)-(R)-phenylpropiolic acid 1-phenylethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-(R)-phenylpropiolic acid 1-phenylethylamine

There total 3 articles about (-)-(R)-phenylpropiolic acid 1-phenylethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(R)-1-phenyl-ethyl-amine (3886-69-9) + phenylpropyolic acid (637-44-5) → (-)-(R)-phenylpropiolic acid 1-phenylethylamine (86980-83-8)

Guidance literature:

phenylpropyolic acid; With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 20 ℃;

(R)-1-phenyl-ethyl-amine; In tetrahydrofuran;

DOI:10.1002/chem.201500397

Reference yield:

phenylpropyolic acid (637-44-5) → (-)-(R)-phenylpropiolic acid 1-phenylethylamine (86980-83-8)

Guidance literature:

Multi-step reaction with 2 steps

1: thionylchlorid / Ambient temperature

2: diethyl ether / 10 h / Ambient temperature

With thionyl chloride; In diethyl ether;

DOI:10.1016/0022-328X(83)85029-3

Reference yield:

phenylpropiolyl chloride (7299-58-3) + (R)-1-phenyl-ethyl-amine (3886-69-9) → (-)-(R)-phenylpropiolic acid 1-phenylethylamine (86980-83-8)

Guidance literature:

In diethyl ether; for 10h; Yield given; Ambient temperature;

DOI:10.1016/0022-328X(83)85029-3

upstream raw materials:

phenylpropiolyl chloride

(R)-1-phenyl-ethyl-amine

phenylpropyolic acid

Downstream raw materials:

(2E)-3-phenyl-N-[(1R)-1-phenylethyl]-2-propenamide

Refernces

• 1、 Nogami, Marina,Hirano, Keiichi,Morimoto, Kensuke,Tanioka, Masaru,Miyamoto, Kazunori,Muranaka, Atsuya,Uchiyama, Masanobu. "Alkynylboration Reaction Leading to Boron-Containing π-Extended cis-Stilbenes as a Highly Tunable Fluorophore". supporting information. p. 3392 - 3395. Retrieved 2019/05/10.