trifluoromethanesulfonic acid 2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-phenyl ester

Base Information

• Chemical Name: trifluoromethanesulfonic acid 2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-phenyl ester
• CAS No.: 960401-12-1
• Molecular Formula: C₂₂H₁₈F₃NO₆S₂
• Molecular Weight: 513.515
• Mol file: 960401-12-1.mol

Synonyms:trifluoromethanesulfonic acid 2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-phenyl ester

Chemical Property of trifluoromethanesulfonic acid 2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trifluoromethanesulfonic acid 2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-phenyl ester

There total 8 articles about trifluoromethanesulfonic acid 2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-methoxy-phenyl)-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one (960289-08-1) → trifluoromethanesulfonic acid 2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-phenyl ester (960401-12-1)

Guidance literature:

Multi-step reaction with 3 steps

1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 16 h / Heating / reflux

2: potassium hydroxide; ethanol; water / 10 h

3: pyridine / 20 °C

With pyridine; potassium hydroxide; ethanol; water; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane;

Reference yield:

4,5-dihydro-6H-cyclopenta[b]thiophen-6-one (5650-52-2) → trifluoromethanesulfonic acid 2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-phenyl ester (960401-12-1)

Guidance literature:

Multi-step reaction with 6 steps

1: hydroxylamine hydrochloride; sodium acetate / methanol / 20 °C

2: bromine; acetic acid / 1 h / 0 °C

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; 1,2-dimethoxyethane; water

4: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 16 h / Heating / reflux

5: potassium hydroxide; ethanol; water / 10 h

6: pyridine / 20 °C

With pyridine; potassium hydroxide; ethanol; hydroxylamine hydrochloride; water; bromine; sodium acetate; sodium carbonate; caesium carbonate; acetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; water;

Reference yield:

(2-thiophen-3-yl-ethyl)-carbamic acid ethyl ester (960289-02-5) → trifluoromethanesulfonic acid 2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-phenyl ester (960401-12-1)

Guidance literature:

Multi-step reaction with 6 steps

1: phosphorus pentoxide / 3.75 h / 110 °C

2: bromine; acetic acid / 1 h / 0 °C

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; 1,2-dimethoxyethane; water

4: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 16 h / Heating / reflux

5: potassium hydroxide; ethanol; water / 10 h

6: pyridine / 20 °C

With pyridine; potassium hydroxide; ethanol; water; bromine; phosphorus pentoxide; sodium carbonate; caesium carbonate; acetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; water;

upstream raw materials:

2-(4-methoxy-phenyl)-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one

4,5-dihydro-6H-cyclopenta[b]thiophen-6-one

toluene-4-sulfonic acid 4-bromo-2-methoxy-phenyl ester

(2-thiophen-3-yl-ethyl)-carbamic acid ethyl ester

Downstream raw materials:

2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-benzoic acid methyl ester