2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-benzoic acid methyl ester

Base Information

Chemical Name:2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-benzoic acid methyl ester
CAS No.:960401-13-2
Molecular Formula:C₂₃H₂₁NO₅S
Molecular Weight:423.489
Hs Code.:

Synonyms:2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-benzoic acid methyl ester

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Chemical Property of 2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-benzoic acid methyl ester

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Technology Process of 2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-benzoic acid methyl ester

There total 8 articles about 2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 67-56-1
methanol

: 960401-12-1
trifluoromethanesulfonic acid 2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-phenyl ester

: 201230-82-2
carbon monoxide

: 960401-13-2
2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-benzoic acid methyl ester

Guidance literature:: With triethylamine; palladium diacetate; 1,4-di(diphenylphosphino)-butane; In acetonitrile; at 100 ℃; for 6h; under 5931.67 Torr;

Reference yield:

: 960289-08-1
2-(4-methoxy-phenyl)-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one

: 960401-13-2
2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 16 h / Heating / reflux

2: potassium hydroxide; ethanol; water / 10 h

3: pyridine / 20 °C

4: triethylamine / palladium diacetate; 1,4-di(diphenylphosphino)-butane / acetonitrile / 6 h / 100 °C / 5931.67 Torr

With pyridine; potassium hydroxide; ethanol; water; caesium carbonate; triethylamine; palladium diacetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,4-di(diphenylphosphino)-butane; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; acetonitrile;

Reference yield:

: 5650-52-2
4,5-dihydro-6H-cyclopenta[b]thiophen-6-one

: 960401-13-2
2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: hydroxylamine hydrochloride; sodium acetate / methanol / 20 °C

2: bromine; acetic acid / 1 h / 0 °C

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; 1,2-dimethoxyethane; water

4: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 16 h / Heating / reflux

5: potassium hydroxide; ethanol; water / 10 h

6: pyridine / 20 °C

7: triethylamine / palladium diacetate; 1,4-di(diphenylphosphino)-butane / acetonitrile / 6 h / 100 °C / 5931.67 Torr

With pyridine; potassium hydroxide; ethanol; hydroxylamine hydrochloride; water; bromine; sodium acetate; sodium carbonate; caesium carbonate; acetic acid; triethylamine; palladium diacetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,4-di(diphenylphosphino)-butane; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; acetonitrile;