(R)-3-((tert-Butoxycarbonyl)amino)-3-(4-methoxyphenyl)propanoic acid

Base Information

• Chemical Name: (R)-3-((tert-Butoxycarbonyl)amino)-3-(4-methoxyphenyl)propanoic acid
• CAS No.: 500788-87-4
• Molecular Formula: C₁₅H₂₁NO₅
• Molecular Weight: 295.335
• DSSTox Substance ID: DTXSID90365690
• Wikidata: Q72449884
• Mol file: 500788-87-4.mol

Synonyms:500788-87-4;(R)-3-((tert-Butoxycarbonyl)amino)-3-(4-methoxyphenyl)propanoic acid;Boc-(R)-3-Amino-3-(4-methoxy-phenyl)-propionic acid;(R)-Boc-4-methoxy-|A-Phe-OH;(3R)-3-(4-methoxyphenyl)-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid;Boc-(R)-3-amino-3-(4-methoxyphenyl)propionic acid;(3R)-3-{[(tert-butoxy)carbonyl]amino}-3-(4-methoxyphenyl)propanoic acid;BOC-BETA-(R)-4-METHOXYPHENYLALANINE;SCHEMBL7226978;DTXSID90365690;MFCD03427938;BOC-(R)-ss-(p-methoxyphenyl)alanine;AKOS013463257;HY-W141806;AC-25436;AS-40721;CS-0201603;EN300-1163405;A871670;boc-(r)-3-amino-3-(4-methoxyphenyl)propanoic acid;(R)-Boc-4-methoxy-beta-Phe-OH, >=98.0% (HPLC);BOC-(R)-AMINO-3-(4-METHOXY-PHENYL)-PROPIONIC ACID;(3R)-3-[(tert-Butoxycarbonyl)amino]-3-(4-methoxyphenyl)propanoic acid

Chemical Property of (R)-3-((tert-Butoxycarbonyl)amino)-3-(4-methoxyphenyl)propanoic acid

Chemical Property:

• Boiling Point: 463.2±45.0 °C(Predicted)
• PKA: 4.38±0.10(Predicted)
• PSA: 84.86000
• Density: 1.167±0.06 g/cm3(Predicted)
• LogP: 3.12660
• Storage Temp.: 2-8°C
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 7
• Exact Mass: 295.14197277
• Heavy Atom Count: 21
• Complexity: 356

Purity/Quality:

97% ^*data from raw suppliers

(R)-3-((tert-Butoxycarbonyl)amino)-3-(4-methoxyphenyl)propanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC(CC(=O)O)C1=CC=C(C=C1)OC
• Isomeric SMILES: CC(C)(C)OC(=O)N[C@H](CC(=O)O)C1=CC=C(C=C1)OC

Technology Process of (R)-3-((tert-Butoxycarbonyl)amino)-3-(4-methoxyphenyl)propanoic acid

There total 8 articles about (R)-3-((tert-Butoxycarbonyl)amino)-3-(4-methoxyphenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

di-tert-butyl dicarbonate (24424-99-5) + 3-amino-3-(4-methoxyphenyl)propionic acid (5678-45-5) → D,L-3-<<(1,1-dimethylethoxy)carbonyl>amino>-3-(4-methoxyphenyl)propanoic acid (96363-20-1,500788-87-4)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; 1.) 0 deg C, 10 min, 2.) RT, 3 h;

DOI:10.1021/jo00213a012

Reference yield: 4.75%

di-tert-butyl dicarbonate (24424-99-5) + (S)-β-amino-β-(4-methoxyphenyl)propionic acid (131690-56-7) → (S)-3-tert-Butoxycarbonylamino-3-(4-methoxy-phenyl)-propionic acid (159990-12-2,500788-87-4)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; for 4h; Ambient temperature;

DOI:10.1016/S0040-4020(01)85520-4

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → D,L-3-<<(1,1-dimethylethoxy)carbonyl>amino>-3-(4-methoxyphenyl)propanoic acid (96363-20-1,500788-87-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 51 percent / ammonium acetate / ethanol; H₂O / 13 h / Heating

2: 88 percent / 1 N NaOH / dioxane; H₂O / 1.) 0 deg C, 10 min, 2.) RT, 3 h

With ammonium acetate; sodium hydroxide; In 1,4-dioxane; ethanol; water;

DOI:10.1021/jo00213a012

upstream raw materials:

di-tert-butyl dicarbonate

3-amino-3-(4-methoxyphenyl)propionic acid

4-methoxy-benzaldehyde

(S)-β-amino-β-(4-methoxyphenyl)propionic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 500788-87-4 Boc-beta-(R)-4-methoxyphenylalanine

Send

Send

Metric Ton KG G Pound L ML

Send

Send