2,5-dioxopyrrolidin-1-yl-5-(2,4-difluorophenoxy)-1-(2-fluoro-2-methylpropyl)-1H-indazole-6-carboxylate

Base Information

Chemical Name:2,5-dioxopyrrolidin-1-yl-5-(2,4-difluorophenoxy)-1-(2-fluoro-2-methylpropyl)-1H-indazole-6-carboxylate
CAS No.:956109-46-9
Molecular Formula:C₂₂H₁₈F₃N₃O₅
Molecular Weight:461.397
Hs Code.:

Synonyms:2,5-dioxopyrrolidin-1-yl-5-(2,4-difluorophenoxy)-1-(2-fluoro-2-methylpropyl)-1H-indazole-6-carboxylate

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Chemical Property of 2,5-dioxopyrrolidin-1-yl-5-(2,4-difluorophenoxy)-1-(2-fluoro-2-methylpropyl)-1H-indazole-6-carboxylate

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Technology Process of 2,5-dioxopyrrolidin-1-yl-5-(2,4-difluorophenoxy)-1-(2-fluoro-2-methylpropyl)-1H-indazole-6-carboxylate

There total 6 articles about 2,5-dioxopyrrolidin-1-yl-5-(2,4-difluorophenoxy)-1-(2-fluoro-2-methylpropyl)-1H-indazole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.4%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 956109-64-1
5-(2,4-difluorophenoxy)-1-(2-fluoro-2-methylpropyl)-1H-indazole-6-carboxylic acid

: 956109-46-9
2,5-dioxopyrrolidin-1-yl-5-(2,4-difluorophenoxy)-1-(2-fluoro-2-methylpropyl)-1H-indazole-6-carboxylate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 5h;

Reference yield:

: 1244783-75-2
5-bromo-4-(2,4-difluorophenoxy)-2-methylbenzenediazonium tetrafluoroborate

: 956109-46-9
2,5-dioxopyrrolidin-1-yl-5-(2,4-difluorophenoxy)-1-(2-fluoro-2-methylpropyl)-1H-indazole-6-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium acetate / ethyl acetate / 1.5 h / 20 °C

2: potassium carbonate / ISOPROPYLAMIDE / 16 - 22 h / 55 - 80 °C

3: diethylamino-sulfur trifluoride / dichloromethane / 1.5 - 2.03 h / -78 - 20 °C

4: water; potassium carbonate / palladium diacetate; 1,3-bis-(diphenylphosphino)propane / methanol / 17 - 20 h / 60 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 20 °C

With diethylamino-sulfur trifluoride; water; potassium acetate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium diacetate; 1,3-bis-(diphenylphosphino)propane; In methanol; dichloromethane; ISOPROPYLAMIDE; ethyl acetate;

Reference yield:

: 765914-74-7
6-bromo-5-(2,4-difluorophenoxy)-1H-indazole

: 956109-46-9
2,5-dioxopyrrolidin-1-yl-5-(2,4-difluorophenoxy)-1-(2-fluoro-2-methylpropyl)-1H-indazole-6-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / ISOPROPYLAMIDE / 16 - 22 h / 55 - 80 °C

2: diethylamino-sulfur trifluoride / dichloromethane / 1.5 - 2.03 h / -78 - 20 °C

3: water; potassium carbonate / palladium diacetate; 1,3-bis-(diphenylphosphino)propane / methanol / 17 - 20 h / 60 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 20 °C

With diethylamino-sulfur trifluoride; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium diacetate; 1,3-bis-(diphenylphosphino)propane; In methanol; dichloromethane; ISOPROPYLAMIDE;