2,2-Dichloro-12-(4-chlorophenyl)dodecanoic acid

Base Information

Chemical Name:2,2-Dichloro-12-(4-chlorophenyl)dodecanoic acid
CAS No.:221564-97-2
Molecular Formula:C₁₈H₂₅Cl₃O₂
Molecular Weight:379.754
Hs Code.:
UNII:TM9XQR923G
DSSTox Substance ID:DTXSID901286589
Nikkaji Number:J1.024.379C

Synonyms:2,2-dichloro-12-(p-chlorophenyl)-dodecanoic acid;BM 17.0744;BM-17.0744;K-111

Suppliers and Price of 2,2-Dichloro-12-(4-chlorophenyl)dodecanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2,2-Dichloro-12-(4-chlorophenyl)dodecanoic acid

Chemical Property:

XLogP3:8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:12
Exact Mass:378.092013
Heavy Atom Count:23
Complexity:326

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1CCCCCCCCCCC(C(=O)O)(Cl)Cl)Cl
Recent EU Clinical Trials:A phase IIa multicentre randomised double-blind, double-dummy study to evaluate the efficacy and safety of K-111 versus Fenofibrate in patients with hyperlipidaemia.

Technology Process of 2,2-Dichloro-12-(4-chlorophenyl)dodecanoic acid

There total 6 articles about 2,2-Dichloro-12-(4-chlorophenyl)dodecanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79-43-6
dichloro-acetic acid

: 178671-35-7
1-Bromo-10-(4-chlorophenyl)-decane

: 221564-97-2
2,2-dichloro-12-(4-chlorophenyl)dodecanoic acid

Guidance literature:: With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -30 ℃; Yield given;
DOI:10.1016/S0223-5234(99)80029-4

Reference yield:

: 4101-68-2
1,10-dibromodecane

: 221564-97-2
2,2-dichloro-12-(4-chlorophenyl)dodecanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 24 percent / Li₂CuCl₄ / tetrahydrofuran / 18 h / Ambient temperature

2: BuLi, iPr₂NH / hexane; tetrahydrofuran / -30 °C

With n-butyllithium; dilithium tetrachlorocuprate; diisopropylamine; In tetrahydrofuran; hexane;
DOI:10.1016/S0223-5234(99)80029-4

Reference yield:

: 873-77-8
(4-chlorphenyl)magnesium bromide

: 221564-97-2
2,2-dichloro-12-(4-chlorophenyl)dodecanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 24 percent / Li₂CuCl₄ / tetrahydrofuran / 18 h / Ambient temperature

2: BuLi, iPr₂NH / hexane; tetrahydrofuran / -30 °C

With n-butyllithium; dilithium tetrachlorocuprate; diisopropylamine; In tetrahydrofuran; hexane;
DOI:10.1016/S0223-5234(99)80029-4