178671-35-7Relevant academic research and scientific papers
METHOD FOR PRODUCING 2,2-DICHLORO-12-(4-HALOPHENYL)DODECANATE SALT AND METHOD FOR PRODUCING PRODUCTION INTERMEDIATE THEREOF
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Page/Page column 17, (2008/06/13)
Disclosed is a commercially suitable method for producing a 1-substituted-10-(4-halophenyl)decane with high yield in a short time without producing 4,4'-dichlorobiphenyl (an environmental pollutant). Also disclosed is a commercially suitable method for producing a 2,2-dichloro-12-(4-halophenyl)dodecanate salt with high yield by a simple process. Specifically disclosed is a method for producing a 1-substituted-10-(4-halophenyl)decane characterized by reacting a 4-halobenzylmagnesium halide with a 1,9-disubstituted nonane. Also specifically disclosed is a method for producing a 2,2-dichloro-12-(4-halophenyl)dodecanate salt characterized by comprising a first step for obtaining a 2,2-dichloro-12-(4-halophenyl)dodecanoic acid ester by reacting a 1-iodo-10-(4-halophenyl)decane and a dichloroacetic acid ester in the presence of a base, and a second step for converting the 2,2-dichloro-12-(4-halophenyl)dodecanoic acid ester into a 2,2-dichloro-12-(4-halophenyl)dodecanate salt. Further specifically disclosed are 1-iodo-10-(4-chlorophenyl)decane and a method for producing the same.
2,2-Dichloroalkanecarboxylic acids, processes for their production and pharmaceutical agents containing these
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, (2008/06/13)
Pharmaceutical agents for treating diabetus mellitus which contain a compound of formula I STR1 as the active substance, in which A, B, A' and W have the meanings stated in the claims, new compounds of formula I as well as processes for their production.
ω-Substituted alkyl carboxylic acids as antidiabetic and lipid-lowering agents
Meyer, Kirstin,Voss, Edgar,Neidlein, Richard,Kuehnle, Hans-Frieder,Pill, Johannes
, p. 775 - 787 (2007/10/03)
In screening experiments certain ω-substituted alkyl carboxylic acids were found to produce an increase in insulin-stimulated 14C-acetate incorporation into triglycerides, which may indicate an improvement in the action of insulin. Antidiabetic
