(R)-4-(tert-butyldiphenylsilyloxy)-2-((tert-butyldiphenylsilyloxy)methyl)butanal

Base Information

Chemical Name:(R)-4-(tert-butyldiphenylsilyloxy)-2-((tert-butyldiphenylsilyloxy)methyl)butanal
CAS No.:1417795-79-9
Molecular Formula:C₃₇H₄₆O₃Si₂
Molecular Weight:594.941
Hs Code.:

Synonyms:(R)-4-(tert-butyldiphenylsilyloxy)-2-((tert-butyldiphenylsilyloxy)methyl)butanal

Suppliers and Price of (R)-4-(tert-butyldiphenylsilyloxy)-2-((tert-butyldiphenylsilyloxy)methyl)butanal

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-(tert-butyldiphenylsilyloxy)-2-((tert-butyldiphenylsilyloxy)methyl)butanal

Chemical Property:

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Technology Process of (R)-4-(tert-butyldiphenylsilyloxy)-2-((tert-butyldiphenylsilyloxy)methyl)butanal

There total 8 articles about (R)-4-(tert-butyldiphenylsilyloxy)-2-((tert-butyldiphenylsilyloxy)methyl)butanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1417795-78-8
(S)-4-(tert-butyldiphenylsilyloxy)-2-((tert-butyldiphenylsilyloxy)methyl)butan-1-ol

: 1417795-79-9
(R)-4-(tert-butyldiphenylsilyloxy)-2-((tert-butyldiphenylsilyloxy)methyl)butanal

Guidance literature:: (S)-4-(tert-butyldiphenylsilyloxy)-2-((tert-butyldiphenylsilyloxy)methyl)butan-1-ol; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.833333h;

With triethylamine; In dichloromethane; at -78 - 20 ℃;
DOI:10.1016/j.tet.2012.11.051

Reference yield:

: 138499-16-8
2-[(tert-butyldiphenylsilyl)oxy]ethanol

: 1417795-79-9
(R)-4-(tert-butyldiphenylsilyloxy)-2-((tert-butyldiphenylsilyloxy)methyl)butanal

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1H-imidazole; triphenylphosphine; iodine / tetrahydrofuran / 2 h / -20 - 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

2.2: 12 h / Reflux

3.1: lithium aluminium tetrahydride / diethyl ether / 1 h / 0 °C

4.1: lipase PS-D immobilized on diatomite / di-isopropyl ether / 20 °C / Molecular sieve; Inert atmosphere; Enzymatic reaction

5.1: 1H-imidazole; dmap / dichloromethane / 3 h / 0 - 20 °C

6.1: potassium carbonate; methanol / 20 °C

7.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C

7.2: -78 - 20 °C

With 1H-imidazole; methanol; dmap; lithium aluminium tetrahydride; oxalyl dichloride; lipase PS-D immobilized on diatomite; iodine; sodium hydride; potassium carbonate; dimethyl sulfoxide; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; di-isopropyl ether; mineral oil; 7.1: |Swern Oxidation;
DOI:10.1016/j.tet.2012.11.051

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1417795-79-9
(R)-4-(tert-butyldiphenylsilyloxy)-2-((tert-butyldiphenylsilyloxy)methyl)butanal

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1H-imidazole; dmap / tetrahydrofuran / 24 h / 0 - 20 °C

2.1: 1H-imidazole; triphenylphosphine; iodine / tetrahydrofuran / 2 h / -20 - 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

3.2: 12 h / Reflux

4.1: lithium aluminium tetrahydride / diethyl ether / 1 h / 0 °C

5.1: lipase PS-D immobilized on diatomite / di-isopropyl ether / 20 °C / Molecular sieve; Inert atmosphere; Enzymatic reaction

6.1: 1H-imidazole; dmap / dichloromethane / 3 h / 0 - 20 °C

7.1: potassium carbonate; methanol / 20 °C

8.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C

8.2: -78 - 20 °C

With 1H-imidazole; methanol; dmap; lithium aluminium tetrahydride; oxalyl dichloride; lipase PS-D immobilized on diatomite; iodine; sodium hydride; potassium carbonate; dimethyl sulfoxide; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; di-isopropyl ether; mineral oil; 8.1: |Swern Oxidation;
DOI:10.1016/j.tet.2012.11.051