6833-15-4

Basic information

• Product Name: 4-CHLOROBENZANILIDE
• Synonyms: 4-CHLOROBENZANILIDE;4-Chloro-N-phenylbenzamide;N-Phenyl-4-chlorobenzamide;N-Phenyl-p-chlorobenzamide;4-Chlorobenzanilide,98%
• CAS NO: 6833-15-4
• Molecular Formula: C₁₃H₁₀ClNO
• Molecular Weight: 231.68
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 6833-15-4.mol
• Article Data: 146

Chemical Properties

• Melting Point: 199-201 °C(lit.)
• Boiling Point: 288.6 °C at 760 mmHg
• Flash Point: 128.3 °C
• Appearance: /Solid
• Density: 1.285 g/cm³
• Vapor Pressure: 0.00232mmHg at 25°C
• Refractive Index: 1.649
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-CHLOROBENZANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLOROBENZANILIDE(6833-15-4)
• EPA Substance Registry System: 4-CHLOROBENZANILIDE(6833-15-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 6833-15-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H10ClNO/c14-11-8-6-10(7-9-11)13(16)15-12-4-2-1-3-5-12/h1-9H,(H,15,16)

Upstream product

• 2998-98-3 (Z)-(4-chlorophenyl)(phenyl)methanone oxime 
• 104-88-1 4-chlorobenzaldehyde 
• 122-01-0 4-chloro-benzoyl chloride 
• 62-53-3 aniline 
• 67-56-1 methanol 
• 27704-37-6 2,2,2-trichloro-1-(4-chlorophenyl)ethanone 
• 56-23-5 tetrachloromethane 
• 13211-25-1 4-chloro-benzophenone-seqcis-chloroimine 
• 7647-18-9 antimonypentachloride 
• 13211-26-2 4-chloro-benzophenone-seqtrans-chloroimine 
• 2998-98-3 4-cholorobenzophenone oxime 
• 2362-79-0 N-(4-chlorobenzylidene)aniline 
• 1227476-15-4 Azobenzene 
• 6244-75-3 4-chloro-N-phenylthiobenzamide 

Downstream Products

• 129120-25-8 (4-chlorophenyl)(4-(dimethylamino)phenyl)methanone 
• 54595-72-1 1'-benzyl-6-chloro-spiro[isobenzofuran-1,4'-piperidin]-3-one 
• 5892-88-6 (4-Chloro-benzoyl)-phenyl-carbamic acid 2-chloro-1-methyl-ethyl ester 
• 146516-71-4 2,N-dimethyl-4-chloro-benzanilide 
• 38430-13-6 N-Phenyl-4-chlor-benzimid-saeurechlorid 
• 949115-03-1 N-phenyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzamide 
• 1141-35-1 2-(4-chlorophenyl)benzoxazole 
• 4750-61-2 N-(p-chlorobenzyl)aniline 
• 54595-71-0 6-chloro-1'-methyl-spiro[isobenzofuran-1,4'-piperidin]-3-one 
• 104689-75-0 (4-chlorophenyl)(4-(diethylamino)phenyl)methanone 
• 91790-87-3 N,N'-diphenyl-4-chlorobenzamidine 
• 37613-10-8 4-chloro-N-phenyl-benzimidoyl chloride 
• 105702-86-1 4-chloro-4'-(N-methyl-anilino)-benzophenone 
• 65786-54-1 4'-chloro-4-dimethylamino-2-methyl-benzophenone 

Relevant articles and documents

TBAI-catalyzed C–N bond formation through oxidative coupling of benzyl bromides with amines: a new avenue to the synthesis of amides

A new green approach for the synthesis of amide through TBAI-catalyzed oxidative coupling of benzyl bromides with amine was developed in the presence of tert-butyl hydroperoxide (TBHP) as an oxidant. Various electron-donating and withdrawing groups containing benzyl bromides and various amines, were subjected to the reaction and transformed to the corresponding amide in good to excellent yields.

Activated charcoal supported copper nanoparticles: A readily available and inexpensive heterogeneous catalyst for the N-arylation of primary amides and lactams with aryl iodides

A novel heterogeneous copper catalyst has been developed by supporting copper nanoparticles on activated charcoal via in situ reducing copper(II) with aqueous hydrazine as reductant. The characterization of Cu/C catalyst showed that the Cu0 nano-particles were formed on the surface of charcoal. This catalyst displayed good catalytic activities toward the N-arylation of primary amides and lactams with aryl iodides.

Method for promoting acylation of amine or alcohol by carbon dioxide

The invention relates to a method for promoting acylation of amine or alcohol by carbon dioxide, which comprises the following steps of: mixing an amine compound, carboxylate or thiocarboxylate compound and a reaction solvent under the action of carbon dioxide, and reacting to obtain an amide compound, or under the action of carbon dioxide, mixing the alcohol compound, the thiocarboxylate compound and the reaction solvent [gamma]-valerolactone, and reacting to obtain the ester compound. According to the invention, under the promotion action of carbon dioxide, carboxylate or thiocarboxylate is used as an acylation reagent, and amine and alcohol are converted into amide and ester compounds in the absence of a transition metal catalyst, so that acylation reagents such as acyl chloride or anhydride with irritation and corrosivity are avoided; and the method has the advantages of simple operation, mild reaction conditions, high tolerance of substrate functional groups, strong applicability and high yield, and provides an efficient, reliable and economical preparation method for synthesis of amide and ester compounds.