4-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]butanenitrile

Base Information

• Chemical Name: 4-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]butanenitrile
• CAS No.: 916993-74-3
• Molecular Formula: C₁₅H₂₂N₂O₂
• Molecular Weight: 262.352
• Mol file: 916993-74-3.mol

Synonyms:4-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]butanenitrile

Chemical Property of 4-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]butanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]butanenitrile

There total 1 articles about 4-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]butanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

N-methylhomoveratrylamine (3490-06-0) + 4-Chlorobutyronitrile (628-20-6) → 4-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]butanenitrile (916993-74-3)

Guidance literature:

With sodium carbonate; sodium iodide; In tert-butyl alcohol; for 24h; Heating;

DOI:10.1016/j.bmc.2006.07.055

Reference yield: 91.0%

4-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]butanenitrile (916993-74-3) → N-<2-(3,4-dimethoxyphenyl)ethyl>-N-methyl-1,4-butanediamine (127404-85-7)

Guidance literature:

With sodium hydroxide; hydrogen; nickel; In ethanol; for 12h; under 2068.59 Torr;

DOI:10.1016/j.bmc.2006.07.055

Reference yield:

4-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]butanenitrile (916993-74-3) → 2-amino-N-{4-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]butyl}benzamide (916993-79-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / NaOH; hydrogen; nickel / ethanol / 12 h / 2068.59 Torr

2: 80 percent / acetonitrile / 18 h / Heating

With sodium hydroxide; hydrogen; nickel; In ethanol; acetonitrile;

DOI:10.1016/j.bmc.2006.07.055

upstream raw materials:

N-methylhomoveratrylamine

4-Chlorobutyronitrile

Downstream raw materials:

N-<2-(3,4-dimethoxyphenyl)ethyl>-N-methyl-1,4-butanediamine

2-amino-N-{4-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]butyl}benzamide