3-hydroxymethyl-1-phenylbutan-1,4-diol

Base Information

• Chemical Name: 3-hydroxymethyl-1-phenylbutan-1,4-diol
• CAS No.: 147322-00-7
• Molecular Formula: C₁₁H₁₆O₃
• Molecular Weight: 196.246
• Mol file: 147322-00-7.mol

Synonyms:3-hydroxymethyl-1-phenylbutan-1,4-diol

Chemical Property of 3-hydroxymethyl-1-phenylbutan-1,4-diol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-hydroxymethyl-1-phenylbutan-1,4-diol

There total 2 articles about 3-hydroxymethyl-1-phenylbutan-1,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

diethyl phenacylmalonate (94011-49-1) → 3-hydroxymethyl-1-phenylbutan-1,4-diol (147322-00-7)

Guidance literature:

With sodium tetrahydroborate; In methanol; tert-butyl alcohol; for 1h; Heating;

DOI:10.1080/15257779408013231

Reference yield:

1-chloroacetophenone (532-27-4,108321-66-0,164322-25-2) → 3-hydroxymethyl-1-phenylbutan-1,4-diol (147322-00-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) THF, room temperature, 1 h, 2.) room teemperature, overnight

2: 82 percent / NaBH₄ / 2-methyl-propan-2-ol; methanol / 1 h / Heating

With sodium tetrahydroborate; sodium hydride; In methanol; tert-butyl alcohol;

DOI:10.1080/15257779408013231

Reference yield: 98.0%

benzaldehyde dimethyl acetal (1125-88-8) + 3-hydroxymethyl-1-phenylbutan-1,4-diol (147322-00-7) → 5-(2-hydroxy-2-phenylethyl)-2-phenyl-1,3-dioxane (159162-49-9)

Guidance literature:

With toluene-4-sulfonic acid; In tetrahydrofuran; for 4h; Ambient temperature;

DOI:10.1080/15257779408013231

upstream raw materials:

diethyl phenacylmalonate

1-chloroacetophenone

Downstream raw materials:

5-(2-hydroxy-2-phenylethyl)-2-phenyl-1,3-dioxane

5-(2-hydroxyl-2-phenylethyl)-2,2-dimethyl-1,3-dioxane

Phosphorous acid 2-(2,2-dimethyl-[1,3]dioxan-5-yl)-1-phenyl-ethyl ester dimethyl ester

[2-(2,2-Dimethyl-[1,3]dioxan-5-yl)-1-phenyl-ethyl]-phosphonic acid dimethyl ester