Phosphorous acid 2-(2,2-dimethyl-[1,3]dioxan-5-yl)-1-phenyl-ethyl ester dimethyl ester

Base Information

• Chemical Name: Phosphorous acid 2-(2,2-dimethyl-[1,3]dioxan-5-yl)-1-phenyl-ethyl ester dimethyl ester
• CAS No.: 159162-46-6
• Molecular Formula: C₁₆H₂₅O₅P
• Molecular Weight: 328.345
• Mol file: 159162-46-6.mol

Synonyms:

Chemical Property of Phosphorous acid 2-(2,2-dimethyl-[1,3]dioxan-5-yl)-1-phenyl-ethyl ester dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphorous acid 2-(2,2-dimethyl-[1,3]dioxan-5-yl)-1-phenyl-ethyl ester dimethyl ester

There total 4 articles about Phosphorous acid 2-(2,2-dimethyl-[1,3]dioxan-5-yl)-1-phenyl-ethyl ester dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl phenacylmalonate (94011-49-1) → Phosphorous acid 2-(2,2-dimethyl-[1,3]dioxan-5-yl)-1-phenyl-ethyl ester dimethyl ester (159162-46-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / NaBH₄ / 2-methyl-propan-2-ol; methanol / 1 h / Heating

2: 77 percent / p-TsOH*H₂O / 4 h / Ambient temperature

3: tetrazole / acetonitrile / 4 h / Ambient temperature

With 1H-tetrazole; sodium tetrahydroborate; toluene-4-sulfonic acid; In methanol; acetonitrile; tert-butyl alcohol;

DOI:10.1080/15257779408013231

Reference yield:

1-chloroacetophenone (532-27-4,108321-66-0,164322-25-2) → Phosphorous acid 2-(2,2-dimethyl-[1,3]dioxan-5-yl)-1-phenyl-ethyl ester dimethyl ester (159162-46-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) NaH / 1.) THF, room temperature, 1 h, 2.) room teemperature, overnight

2: 82 percent / NaBH₄ / 2-methyl-propan-2-ol; methanol / 1 h / Heating

3: 77 percent / p-TsOH*H₂O / 4 h / Ambient temperature

4: tetrazole / acetonitrile / 4 h / Ambient temperature

With 1H-tetrazole; sodium tetrahydroborate; sodium hydride; toluene-4-sulfonic acid; In methanol; acetonitrile; tert-butyl alcohol;

DOI:10.1080/15257779408013231

Reference yield:

3-hydroxymethyl-1-phenylbutan-1,4-diol (147322-00-7) → Phosphorous acid 2-(2,2-dimethyl-[1,3]dioxan-5-yl)-1-phenyl-ethyl ester dimethyl ester (159162-46-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / p-TsOH*H₂O / 4 h / Ambient temperature

2: tetrazole / acetonitrile / 4 h / Ambient temperature

With 1H-tetrazole; toluene-4-sulfonic acid; In acetonitrile;

DOI:10.1080/15257779408013231

upstream raw materials:

dimethoxy(diethylamino)phosphine

5-(2-hydroxyl-2-phenylethyl)-2,2-dimethyl-1,3-dioxane

diethyl phenacylmalonate

1-chloroacetophenone

Downstream raw materials:

[2-(2,2-Dimethyl-[1,3]dioxan-5-yl)-1-phenyl-ethyl]-phosphonic acid dimethyl ester