Technology Process of (4-pentadecylbenzyl)phosphonic acid
There total 7 articles about (4-pentadecylbenzyl)phosphonic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
dimethyl 4-pentadecylbenzylphosphonate;
With
trimethylsilyl bromide;
In
acetonitrile;
for 1h;
Reflux;
Inert atmosphere;
With
methanol;
at 20 ℃;
for 0.5h;
Inert atmosphere;
DOI:10.1002/cmdc.201000425
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 20 % Pd(OH)2/C; hydrogen / methanol / 2 h / 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere
3.1: phosphorus tribromide / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
4.1: 18 h / Reflux; Inert atmosphere
5.1: trimethylsilyl bromide / acetonitrile / 1 h / Reflux; Inert atmosphere
5.2: 0.5 h / 20 °C / Inert atmosphere
With
lithium aluminium tetrahydride; trimethylsilyl bromide; 20 % Pd(OH)2/C; hydrogen; phosphorus tribromide;
In
tetrahydrofuran; methanol; dichloromethane; acetonitrile;
4.1: Michaelis-Arbuzov reaction;
DOI:10.1002/cmdc.201000425
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: phosphorus tribromide / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
2.1: 18 h / Reflux; Inert atmosphere
3.1: trimethylsilyl bromide / acetonitrile / 1 h / Reflux; Inert atmosphere
3.2: 0.5 h / 20 °C / Inert atmosphere
With
trimethylsilyl bromide; phosphorus tribromide;
In
dichloromethane; acetonitrile;
2.1: Michaelis-Arbuzov reaction;
DOI:10.1002/cmdc.201000425
