1-(5-bromo-2-(1-methylpiperidin-4-ylamino)phenyl)-2-chloroethanone hydrochloride

Base Information

Chemical Name:1-(5-bromo-2-(1-methylpiperidin-4-ylamino)phenyl)-2-chloroethanone hydrochloride
CAS No.:954387-07-6
Molecular Formula:C₁₄H₁₈BrClN₂O*ClH
Molecular Weight:382.128
Hs Code.:

Synonyms:1-(5-bromo-2-(1-methylpiperidin-4-ylamino)phenyl)-2-chloroethanone hydrochloride

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Chemical Property of 1-(5-bromo-2-(1-methylpiperidin-4-ylamino)phenyl)-2-chloroethanone hydrochloride

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Technology Process of 1-(5-bromo-2-(1-methylpiperidin-4-ylamino)phenyl)-2-chloroethanone hydrochloride

There total 4 articles about 1-(5-bromo-2-(1-methylpiperidin-4-ylamino)phenyl)-2-chloroethanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 107-14-2
chloroacetonitrile

: 93591-85-6
N-(4-bromophenyl)-1-methylpiperidin-4-amine

: 954387-07-6
1-(5-bromo-2-(1-methylpiperidin-4-ylamino)phenyl)-2-chloroethanone hydrochloride

Guidance literature:: With boron trichloride; In 1,2-dichloro-ethane; Reflux;
DOI:10.1016/j.bmcl.2011.07.022

Reference yield: 54.7%

: 107-14-2
chloroacetonitrile

: 954387-07-6
1-(5-bromo-2-(1-methylpiperidin-4-ylamino)phenyl)-2-chloroethanone hydrochloride

Guidance literature:: N-(4-bromophenyl)-1-methylpiperidin-4-amine; With boron trichloride; In dichloromethane; at 0 ℃;

chloroacetonitrile; In dichloromethane; at 0 ℃; for 6h; Heating / reflux;

With hydrogenchloride; water; In dichloromethane; at 0 - 20 ℃; for 0.333333h; Heating / reflux;

Reference yield:

: 106-40-1
4-bromo-aniline

: 954387-07-6
1-(5-bromo-2-(1-methylpiperidin-4-ylamino)phenyl)-2-chloroethanone hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 55 °C

2: boron trichloride / 1,2-dichloro-ethane / Reflux

With boron trichloride; sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2011.07.022