N-Methyldesloratadine

Base Information

Chemical Name:N-Methyldesloratadine
CAS No.:38092-89-6
Molecular Formula:C20H21ClN2
Molecular Weight:324.853
Hs Code.:2933399090
European Community (EC) Number:641-012-1,923-094-3
UNII:70V8053T5G
DSSTox Substance ID:DTXSID40191502
Nikkaji Number:J1.329.319H
Wikidata:Q27265894
ChEMBL ID:CHEMBL420316
Mol file:38092-89-6.mol

Synonyms:38092-89-6;8-Chloroazatadine;N-Methyldesloratadine;N-Methyl Desloratadine;8-Chloro-6,11-dihydro-11-(1-methyl-4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine;8-chloro-11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine;Loratadine EP Impurity G;Loratadine impurity G [EP];CHEMBL420316;UNII-70V8053T5G;MFCD06411084;70V8053T5G;8-Chloro-11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-b)pyridine;13-chloro-2-(1-methylpiperidin-4-ylidene)-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaene;5H-Benzo(5,6)cyclohepta(1,2-b)pyridine, 8-chloro-6,11-dihydro-11-(1-methyl-4-piperidinylidene)-;8-chloro-11-(1-methylpiperidin-4-ylidene)-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine;8-Chloro azatadine;8-Chloro-5,6-dihydro-11H-benzo[5,6]Cyclohepto[1,2-b]pyridine-11-one;SCHEMBL4460572;DTXSID40191502;BCP31809;BDBM50031228;STL481882;AKOS005216035;DS-7427;8-Chloro-6,11-dihydro-11-(1-methyl-4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine;AC-26333;SY110869;LORATADINE IMPURITY G [EP IMPURITY];CS-0151108;FT-0671893;LORATADINE EP IMPURITY G (USP RC B);A856099;Q27265894;11-(1-Methylpiperidine-4-ylidene)-8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridine;13-chloro-2-(1-methylpiperidin-4-ylidene)-4-azatricyclo[9.4.0.0^{3,8]pentadeca-1(11),3(8),4,6,12,14-hexaene;5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 8-chloro-6,11-dihydro-11-(1-methyl-4-piperidinylidene)-, (Z)-2-butenedioate (1:1);8-chloro-6,11-dihydro- 11-(1-methyl-4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine;8-chloro-6,11-dihydro-11-(1-methyl-4-piperidinylidene)-5H-benzo-[5,6]-cyclohepta-[1,2-b]-pyridine

Suppliers and Price of N-Methyldesloratadine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
8-Chloro-6-
1mg
$ 460.00

TRC
N-MethylDesloratadine
100mg
$ 75.00

SynQuest Laboratories
8-Chloro-11-[(N-methyl)-4-piperidylidene]-6,11-dihydro-5h-benzo[5,6]cyclohepta[1,2b]pyridine 97%
1 g
$ 96.00

Sigma-Aldrich
Loratadine Related Compound B
15mg
$ 1260.00

Medical Isotopes, Inc.
N-MethylDesloratadine
250 mg
$ 890.00

Crysdot
8-Chloroazatadine 97%
5g
$ 223.00

Crysdot
8-Chloroazatadine 97%
10g
$ 356.00

AvaChem
N-Methyl Desloratadine
5g
$ 495.00

AvaChem
N-Methyl Desloratadine
100mg
$ 95.00

AvaChem
N-Methyl Desloratadine
1g
$ 195.00

Total 128 raw suppliers

Chemical Property of N-Methyldesloratadine

Chemical Property:

Appearance/Colour:Red oil
Vapor Pressure:3.64E-09mmHg at 25°C
Melting Point:106-109 °C
Refractive Index:1.622
Boiling Point:474.3 °C at 760 mmHg
PKA:8.67±0.20(Predicted)
Flash Point:240.7 °C
PSA：16.13000
Density:1.205 g/cm³
LogP:4.29900
Storage Temp.:-20?C Freezer
XLogP3:4.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:324.1393264
Heavy Atom Count:23
Complexity:451

Purity/Quality:

99%, ^*data from raw suppliers

8-Chloro-6- ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1
Uses An intermediate in the synthesis of Loratadine. Loratadine impurity. N-Methyl Desloratadine (Loratadine EP Impurity G; Loratadine USP Related Compound B) is an intermediate in the synthesis of Loratadine. Loratadine impurity.

Technology Process of N-Methyldesloratadine

There total 16 articles about N-Methyldesloratadine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%