(4R,5R)-5-Hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid 4-methoxy-benzylamide

Base Information

Chemical Name:(4R,5R)-5-Hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid 4-methoxy-benzylamide
CAS No.:137664-58-5
Molecular Formula:C₁₅H₂₁NO₅
Molecular Weight:295.335
Hs Code.:

Synonyms:(4R,5R)-5-Hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid 4-methoxy-benzylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R,5R)-5-Hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid 4-methoxy-benzylamide

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Technology Process of (4R,5R)-5-Hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid 4-methoxy-benzylamide

There total 1 articles about (4R,5R)-5-Hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid 4-methoxy-benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 25581-41-3
D-erythronolactone acetonide

: 2393-23-9
4-methoxy-benzylamine

: 137664-58-5
(4R,5R)-5-Hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid 4-methoxy-benzylamide

Guidance literature:: With trimethylaluminum; In dichloromethane;
DOI:10.1021/ja992135e

Reference yield: 78.0%

: 137664-58-5
(4R,5R)-5-Hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid 4-methoxy-benzylamide

: 137664-59-6,137765-32-3
(3aR,6aS)-6-Hydroxy-5-(4-methoxy-benzyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-4-one

Guidance literature:: With pyridine-SO₃ complex; In dimethyl sulfoxide;
DOI:10.1016/S0040-4039(00)93480-4

Reference yield:

: 137664-58-5
(4R,5R)-5-Hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid 4-methoxy-benzylamide

: 137664-61-0
(3aR,6R,6aR)-6-(3,3-Dimethyl-2-oxo-butyl)-5-(4-methoxy-benzyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: SO₃*pyridine; DMSO; Et₃N

2: pyridine

3: 81 percent / BF₃*Et₂O / CH₂Cl₂ / 0 - 20 °C

With pyridine; pyridine-SO₃ complex; boron trifluoride diethyl etherate; dimethyl sulfoxide; triethylamine; In dichloromethane; 1: Oxidation / 2: Acetylation / 3: Substitution;
DOI:10.1021/ja992135e