2-fluoro-4-(5-methanesulfonyloxymethyl-2-oxo-oxazolidin-3-yl)-benzoic acid tert-butyl ester

Base Information

Chemical Name:2-fluoro-4-(5-methanesulfonyloxymethyl-2-oxo-oxazolidin-3-yl)-benzoic acid tert-butyl ester
CAS No.:324789-64-2
Molecular Formula:C₁₆H₂₀FNO₇S
Molecular Weight:389.402
Hs Code.:

2-fluoro-4-(5-methanesulfonyloxymethyl-2-oxo-oxazolidin-3-yl)-benzoic acid <i>tert</i>-butyl ester

Synonyms:2-fluoro-4-(5-methanesulfonyloxymethyl-2-oxo-oxazolidin-3-yl)-benzoic acid tert-butyl ester

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Chemical Property of 2-fluoro-4-(5-methanesulfonyloxymethyl-2-oxo-oxazolidin-3-yl)-benzoic acid tert-butyl ester

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Technology Process of 2-fluoro-4-(5-methanesulfonyloxymethyl-2-oxo-oxazolidin-3-yl)-benzoic acid tert-butyl ester

There total 4 articles about 2-fluoro-4-(5-methanesulfonyloxymethyl-2-oxo-oxazolidin-3-yl)-benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124-63-0
methanesulfonyl chloride

: 324788-99-0
5-(R)-hydroxymethyl-3-[4'-tert-butoxycarbonyl-3'-fluorophenyl]oxazolidine-2-one

: 324789-64-2
2-fluoro-4-(5-methanesulfonyloxymethyl-2-oxo-oxazolidin-3-yl)-benzoic acid tert-butyl ester

Guidance literature:: With TEA; In dichloromethane;
DOI:10.1016/j.bmcl.2003.07.021

Reference yield:

: 1427-07-2
2-fluoro-4-nitrotoluene

: 324789-64-2
2-fluoro-4-(5-methanesulfonyloxymethyl-2-oxo-oxazolidin-3-yl)-benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: CrO₃; AcOH

2: SOCl₂ / CH₂Cl₂

3: tetrahydrofuran

4: Fe; aq. NH₄Cl

5: pyridine / CH₂Cl₂

6: TEA / CH₂Cl₂

With pyridine; chromium(VI) oxide; thionyl chloride; TEA; iron; ammonium chloride; acetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2003.07.021

Reference yield:

: 403-23-6
2-fluoro-4-nitrobenzoyl chloride

: 324789-64-2
2-fluoro-4-(5-methanesulfonyloxymethyl-2-oxo-oxazolidin-3-yl)-benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran

2: Fe; aq. NH₄Cl

3: pyridine / CH₂Cl₂

4: TEA / CH₂Cl₂

With pyridine; TEA; iron; ammonium chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2003.07.021