N-(2-chloro-6-fluorophenyl)-2-(8-methyl-6-phenyldipyrazolo[3,4-b:3',4-d]pyridin-1(6H)-yl)acetamide

Base Information

• Chemical Name: N-(2-chloro-6-fluorophenyl)-2-(8-methyl-6-phenyldipyrazolo[3,4-b:3',4-d]pyridin-1(6H)-yl)acetamide
• CAS No.: 1263104-22-8
• Molecular Formula: C₂₂H₁₆ClFN₆O
• Molecular Weight: 434.86

Synonyms:N-(2-chloro-6-fluorophenyl)-2-(8-methyl-6-phenyldipyrazolo[3,4-b:3',4-d]pyridin-1(6H)-yl)acetamide

Chemical Property of N-(2-chloro-6-fluorophenyl)-2-(8-methyl-6-phenyldipyrazolo[3,4-b:3',4-d]pyridin-1(6H)-yl)acetamide

Chemical Property:

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Technology Process of N-(2-chloro-6-fluorophenyl)-2-(8-methyl-6-phenyldipyrazolo[3,4-b:3',4-d]pyridin-1(6H)-yl)acetamide

There total 3 articles about N-(2-chloro-6-fluorophenyl)-2-(8-methyl-6-phenyldipyrazolo[3,4-b:3',4-d]pyridin-1(6H)-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.29%

C8H6BrClFNO (1215294-15-7) + 8-methyl-6-phenyl-1,6-dihydrodipyrazolo[3,4-b:3',4'-d]pyridine (1263104-14-8) → N-(2-chloro-6-fluorophenyl)-2-(8-methyl-6-phenyldipyrazolo[3,4-b:3',4-d]pyridin-1(6H)-yl)acetamide (1263104-22-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 55 - 60 ℃; for 6h;

DOI:10.1007/s10895-010-0622-4

Reference yield:

(4-chloro-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone (1263104-04-6) → N-(2-chloro-6-fluorophenyl)-2-(8-methyl-6-phenyldipyrazolo[3,4-b:3',4-d]pyridin-1(6H)-yl)acetamide (1263104-22-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / ethanol / 8 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 6 h / 55 - 60 °C

With potassium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1007/s10895-010-0622-4

Reference yield:

4-chloro-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester (81153-44-8) → N-(2-chloro-6-fluorophenyl)-2-(8-methyl-6-phenyldipyrazolo[3,4-b:3',4-d]pyridin-1(6H)-yl)acetamide (1263104-22-8)

Guidance literature:

Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / dichloromethane; toluene / 2 h / -78 °C

2: potassium carbonate / ethanol / 8 h / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 6 h / 55 - 60 °C

With diisobutylaluminium hydride; potassium carbonate; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1007/s10895-010-0622-4

upstream raw materials:

C₈H₆BrClFNO

8-methyl-6-phenyl-1,6-dihydrodipyrazolo[3,4-b:3',4'-d]pyridine

(4-chloro-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone

4-chloro-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester

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