4-Chloro-D-phenylalanine methyl ester hydrochloride

Base Information

• Chemical Name: 4-Chloro-D-phenylalanine methyl ester hydrochloride
• CAS No.: 33965-47-8
• Molecular Formula: C₁₀H₁₂ClNO₂*ClH
• Molecular Weight: 250.125
• Hs Code.: 2922499990
• Mol file: 33965-47-8.mol

Synonyms:Alanine,3-(p-chlorophenyl)-, methyl ester, hydrochloride, D- (8CI); D-Phenylalanine, 4-chloro-,methyl ester, hydrochloride (9CI)

Chemical Property of 4-Chloro-D-phenylalanine methyl ester hydrochloride

Chemical Property:

• Vapor Pressure: 0.000123mmHg at 25°C
• Boiling Point: 330oC at 760 mmHg
• Flash Point: 153.4oC
• PSA: 52.32000
• LogP: 2.88510
• Storage Temp.: 2-8°C
• Solubility.: DMSO (Slightly), Ethanol (Sparingly), Methanol (Sparingly)

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-D-phenylalanine methyl ester hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Chloro-D-phenylalanine Methyl Ester Hydrochloride is one of the enatiomer in 4-Chloro-DL-phenylalanine Methyl Ester Hydrochloride (C377780) which is a tryptophan (T947200) hydroxylase (TPH) inhibitor and a serotonin (S274980) synthesis inhibitor. 4-Chloro-D-phenylalanine methyl ester hydrochloride is also known to induce memory deficits in rats.

Technology Process of 4-Chloro-D-phenylalanine methyl ester hydrochloride

There total 17 articles about 4-Chloro-D-phenylalanine methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + DL-Phe(4Cl) (7424-00-2,1991-78-2) → 2-amino-3-(4-chlorophenyl)propionic acid methyl ester hydrochloride (14173-40-1,23434-91-5,33965-47-8,60594-65-2)

Guidance literature:

With thionyl chloride; for 4h; Heating;

DOI:10.1021/ja8018687

Reference yield: 66.0%

methanol (67-56-1) + p-chlorophenylalanine (14173-39-8,1991-78-2) → (S)-2-amino-3-(4-chloro-phenyl)-propionic acid methyl ester hydrochloride (14173-40-1,23434-91-5,33965-47-8,60594-65-2)

Guidance literature:

With hydrogenchloride; at 0 ℃;

DOI:10.1002/ardp.201100109

Reference yield:

(2S)-2-azido-3-(4-chlorophenyl)propionic acid methyl ester (182249-59-8) → (S)-2-amino-3-(4-chloro-phenyl)-propionic acid methyl ester hydrochloride (14173-40-1,23434-91-5,33965-47-8,60594-65-2)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; for 4h; under 760 Torr; Ambient temperature;

DOI:10.1021/jo960956l

upstream raw materials:

DL-Phe(4Cl)

methanol

2-acetylamino-2-(4-chlorobenzyl)malonic acid diethyl ester

2-amino-3-(4-chlorophenyl)propionic acid hydrochloride

Downstream raw materials:

methyl 4-chloro-N-formylphenylalaninate

C₁₃H₁₂ClNO₃

4-chloro-(RS)-phenylalaninamide hydrochloride

p-chlorophenylalanine

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