4-methyl-N-[(1S)-1-(pentyloxy)prop-2-en-1-yl]-N-[(1S)-1-phenylbut-3-yn-1-yl]benzene-1-sulfonamide

Base Information

Chemical Name:4-methyl-N-[(1S)-1-(pentyloxy)prop-2-en-1-yl]-N-[(1S)-1-phenylbut-3-yn-1-yl]benzene-1-sulfonamide
CAS No.:1361969-76-7
Molecular Formula:C₂₅H₃₁NO₃S
Molecular Weight:425.592
Hs Code.:

Synonyms:4-methyl-N-[(1S)-1-(pentyloxy)prop-2-en-1-yl]-N-[(1S)-1-phenylbut-3-yn-1-yl]benzene-1-sulfonamide

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Chemical Property of 4-methyl-N-[(1S)-1-(pentyloxy)prop-2-en-1-yl]-N-[(1S)-1-phenylbut-3-yn-1-yl]benzene-1-sulfonamide

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Technology Process of 4-methyl-N-[(1S)-1-(pentyloxy)prop-2-en-1-yl]-N-[(1S)-1-phenylbut-3-yn-1-yl]benzene-1-sulfonamide

There total 4 articles about 4-methyl-N-[(1S)-1-(pentyloxy)prop-2-en-1-yl]-N-[(1S)-1-phenylbut-3-yn-1-yl]benzene-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1306740-68-0
(S)-4-methyl-N-(1-phenylbut-3-yn-1-yl)benzenesulfonamide

: 166319-26-2
1-(propa-1,2-dien-1-yloxy)pentane

: 1361969-76-7
4-methyl-N-[(1S)-1-(pentyloxy)prop-2-en-1-yl]-N-[(1S)-1-phenylbut-3-yn-1-yl]benzene-1-sulfonamide

Guidance literature:: With palladium diacetate; (1R,2R)-1,2-bis[(2-diphenylphosphanyl)benzoylamino]cyclohexane; triethylamine; In dichloromethane; at 20 ℃; optical yield given as %de; diastereoselective reaction; sealed tube; Inert atmosphere;
DOI:10.1021/ja2116298

Reference yield:

: 110-53-2
1-Bromopentane

: 1361969-76-7
4-methyl-N-[(1S)-1-(pentyloxy)prop-2-en-1-yl]-N-[(1S)-1-phenylbut-3-yn-1-yl]benzene-1-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 1 h / 0 - 20 °C / Inert atmosphere

1.2: 3 h / 0 - 20 °C / Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

3.1: palladium diacetate; (1R,2R)-1,2-bis[(2-diphenylphosphanyl)benzoylamino]cyclohexane; triethylamine / dichloromethane / 20 °C / sealed tube; Inert atmosphere

With potassium tert-butylate; palladium diacetate; (1R,2R)-1,2-bis[(2-diphenylphosphanyl)benzoylamino]cyclohexane; triethylamine; potassium hydroxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/ja2116298

Reference yield:

: 24395-14-0,149769-84-6,151003-26-8,62596-62-7
(R)-2-phenyl-N-tosylaziridine

: 1361969-76-7
4-methyl-N-[(1S)-1-(pentyloxy)prop-2-en-1-yl]-N-[(1S)-1-phenylbut-3-yn-1-yl]benzene-1-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 9 h / 20 °C / Inert atmosphere

2.1: palladium diacetate; (1R,2R)-1,2-bis[(2-diphenylphosphanyl)benzoylamino]cyclohexane; triethylamine / dichloromethane / 20 °C / sealed tube; Inert atmosphere

With n-butyllithium; palladium diacetate; (1R,2R)-1,2-bis[(2-diphenylphosphanyl)benzoylamino]cyclohexane; triethylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ja2116298