(R)-4,4,4-trichloro-3-hydroxy-1-phenyl-1-butanone

Base Information

• Chemical Name: (R)-4,4,4-trichloro-3-hydroxy-1-phenyl-1-butanone
• CAS No.: 196107-42-3
• Molecular Formula: C₁₀H₉Cl₃O₂
• Molecular Weight: 267.539
• Mol file: 196107-42-3.mol

Synonyms:(R)-4,4,4-trichloro-3-hydroxy-1-phenyl-1-butanone

Chemical Property of (R)-4,4,4-trichloro-3-hydroxy-1-phenyl-1-butanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-4,4,4-trichloro-3-hydroxy-1-phenyl-1-butanone

There total 6 articles about (R)-4,4,4-trichloro-3-hydroxy-1-phenyl-1-butanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(R)-(-)-3-hydroxy-4,4,4-trichlorobutyric β-lactone (16493-63-3,16493-62-2,20710-33-2) → (R)-4,4,4-trichloro-3-hydroxy-1-phenyl-1-butanone (196107-42-3)

Guidance literature:

With aluminum (III) chloride; In benzene; at 5 - 20 ℃; Inert atmosphere;

DOI:10.1002/chem.200902896

Reference yield: 89.0%

(R)-(-)-3-hydroxy-4,4,4-trichlorobutyric β-lactone (16493-63-3,16493-62-2,20710-33-2) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → (R)-4,4,4-trichloro-3-hydroxy-1-phenyl-1-butanone (196107-42-3)

Guidance literature:

(R)-(-)-3-hydroxy-4,4,4-trichlorobutyric β-lactone; benzene; With aluminum (III) chloride; at 0 - 20 ℃; for 12h;

With ammonium chloride; In water; benzene; at 0 ℃;

DOI:10.1016/j.tet.2012.04.107

Reference yield:

chloral hydrate (302-17-0) + (R)-N-(1-phenylethylidene)-1-(1-naphthyl)ethylamine (72237-26-4) → (S)-4,4,4-trichloro-3-hydroxy-1-phenyl-1-butanone (188854-65-1) + (R)-4,4,4-trichloro-3-hydroxy-1-phenyl-1-butanone (196107-42-3)

Guidance literature:

chloral hydrate; (R)-N-(1-phenylethylidene)-1-(1-naphthyl)ethylamine; In toluene; at -78 - 20 ℃;

With hydrogenchloride; In toluene; at 20 ℃; for 1h;

DOI:10.1021/ol034461b

upstream raw materials:

chloral hydrate

(R)-N-(1-phenylethylidene)-1-(1-naphthyl)ethylamine

(-)-(R)-N-(1-phenylethyl)-α-methylbenzylideneamine

chloral

Downstream raw materials:

(1S,3R)-4,4,4-trichloro-1-phenylbutane-1,3-diol

(1R,3R)-4,4,4-trichloro-1-phenylbutane-1,3-diol

(3S,5S)-3-azidodihydro-5-phenylfuran-2(3H)-one

(3S,5R)-3-azidodihydro-5-phenylfuran-2(3H)-one