1-methyl-3-(4-chlorophenyl)-9,10-dihydro-4H-pyrazolo<4,5-c><1>benzazepin-10-one

Base Information

• Chemical Name: 1-methyl-3-(4-chlorophenyl)-9,10-dihydro-4H-pyrazolo<4,5-c><1>benzazepin-10-one
• CAS No.: 106148-26-9
• Molecular Formula: C₁₈H₁₄ClN₃O
• Molecular Weight: 323.782
• Mol file: 106148-26-9.mol

Synonyms:1-methyl-3-(4-chlorophenyl)-9,10-dihydro-4H-pyrazolo<4,5-c><1>benzazepin-10-one

Chemical Property of 1-methyl-3-(4-chlorophenyl)-9,10-dihydro-4H-pyrazolo<4,5-c><1>benzazepin-10-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-methyl-3-(4-chlorophenyl)-9,10-dihydro-4H-pyrazolo<4,5-c><1>benzazepin-10-one

There total 4 articles about 1-methyl-3-(4-chlorophenyl)-9,10-dihydro-4H-pyrazolo<4,5-c><1>benzazepin-10-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

ethyl 1-(4-chlorophenyl)-3-methyl-5-(2-aminobenzyl)pyrazole-4-carboxylate (106148-22-5) → 1-methyl-3-(4-chlorophenyl)-9,10-dihydro-4H-pyrazolo<4,5-c><1>benzazepin-10-one (106148-26-9)

Guidance literature:

With sodium methylate; In methanol; Heating; overnight;

DOI:10.1002/jhet.5570230135

Reference yield:

ethyl 2-acetyl-3-oxo-4-(2-nitrophenyl)butanoate (61417-33-2) → 1-methyl-3-(4-chlorophenyl)-9,10-dihydro-4H-pyrazolo<4,5-c><1>benzazepin-10-one (106148-26-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 30 percent / triethylamine / ethanol / 5 h / Heating

2: 83 percent / H₂ / 10percent Pd/C / ethyl acetate / 10 h / 2585.7 Torr

3: 68 percent / CH₃ONa / methanol / Heating; overnight

With hydrogen; sodium methylate; triethylamine; palladium on activated charcoal; In methanol; ethanol; ethyl acetate;

DOI:10.1002/jhet.5570230135

Reference yield:

4-chlorophenylhydrazine hydrochloride (1073-70-7) → 1-methyl-3-(4-chlorophenyl)-9,10-dihydro-4H-pyrazolo<4,5-c><1>benzazepin-10-one (106148-26-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 30 percent / triethylamine / ethanol / 5 h / Heating

2: 83 percent / H₂ / 10percent Pd/C / ethyl acetate / 10 h / 2585.7 Torr

3: 68 percent / CH₃ONa / methanol / Heating; overnight

With hydrogen; sodium methylate; triethylamine; palladium on activated charcoal; In methanol; ethanol; ethyl acetate;

DOI:10.1002/jhet.5570230135

upstream raw materials:

ethyl 1-(4-chlorophenyl)-3-methyl-5-(2-aminobenzyl)pyrazole-4-carboxylate

ethyl 2-acetyl-3-oxo-4-(2-nitrophenyl)butanoate

4-chlorophenylhydrazine hydrochloride

ethyl 1-(4-chlorophenyl)-3-methyl-5-(2-nitrobenzyl)pyrazole-4-carboxylate