2-hydroxy-N-(1-methylpiperidin-3-yl)-2,2-diphenylacetamide

Base Information

Chemical Name:2-hydroxy-N-(1-methylpiperidin-3-yl)-2,2-diphenylacetamide
CAS No.:61609-33-4
Molecular Formula:C₂₀H₂₄N₂O₂
Molecular Weight:324.423
Hs Code.:

Synonyms:2-hydroxy-N-(1-methylpiperidin-3-yl)-2,2-diphenylacetamide

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Chemical Property of 2-hydroxy-N-(1-methylpiperidin-3-yl)-2,2-diphenylacetamide

Chemical Property:

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Technology Process of 2-hydroxy-N-(1-methylpiperidin-3-yl)-2,2-diphenylacetamide

There total 9 articles about 2-hydroxy-N-(1-methylpiperidin-3-yl)-2,2-diphenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 2-hydroxy-2,2-diphenyl-N-(piperidin-3-yl)acetamide

: 74-88-4
methyl iodide

: 61609-33-4
2-hydroxy-N-(1-methylpiperidin-3-yl)-2,2-diphenylacetamide

Guidance literature:: 2-hydroxy-2,2-diphenyl-N-(piperidin-3-yl)acetamide; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; at 25 ℃; for 3h;

Reference yield:

: C₁₃H₁₉NO₃S

: 61609-33-4
2-hydroxy-N-(1-methylpiperidin-3-yl)-2,2-diphenylacetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium azide / N,N-dimethyl-formamide / 2 h / 100 °C

2.1: triphenylphosphine; water / tetrahydrofuran / 2 h / 70 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 20 °C

4.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 3 h / 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

5.2: 3 h / 25 °C

With 4-methyl-morpholine; sodium azide; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 14813-01-5
1-benzyl-3-hydroxypiperidine

: 61609-33-4
2-hydroxy-N-(1-methylpiperidin-3-yl)-2,2-diphenylacetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 3 h / 20 °C

2.1: sodium azide / N,N-dimethyl-formamide / 2 h / 100 °C

3.1: triphenylphosphine; water / tetrahydrofuran / 2 h / 70 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 20 °C

5.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 3 h / 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

6.2: 3 h / 25 °C

With 4-methyl-morpholine; sodium azide; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;