2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanal

Base Information

Chemical Name:2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanal
CAS No.:1264296-55-0
Molecular Formula:C₂₂H₁₈ClN₃O
Molecular Weight:375.857
Hs Code.:

Synonyms:2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanal

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Chemical Property of 2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanal

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Technology Process of 2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanal

There total 10 articles about 2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1264296-02-7
2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropan-1-ol

: 1264296-55-0
2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanal

Guidance literature:: 2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropan-1-ol; With pyridine; Dess-Martin periodane; In dichloromethane; at 20 ℃; for 3h;

With sodium carbonate; sodium thiosulfate; In dichloromethane; water; for 0.333333h;

Reference yield:

: 107449-78-5
ethyl α-methyl-α-benzylacetoacetate

: 1264296-55-0
2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanal

Guidance literature:: Multi-step reaction with 10 steps

1.1: toluene-4-sulfonic acid; orthoformic acid triethyl ester / 55 °C

2.1: lithium hydroxide / ethylene glycol / 0.5 h / 200 °C

3.1: hydrogenchloride / water

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.17 h / 0 °C / Reflux

4.2: 0 °C

5.1: hydrogenchloride; water / acetone / 1 h

6.1: dmap; triethylamine / dichloromethane / 2 h

7.1: 16 h / 125 °C

8.1: hydrogenchloride / 1,4-dioxane; ethanol / 0.25 h / 150 °C / Irradiation with microwave

9.1: sodium methylate / methanol / 1.5 h

10.1: Dess-Martin periodane; pyridine / dichloromethane / 3 h / 20 °C

10.2: 0.33 h

With pyridine; hydrogenchloride; dmap; lithium aluminium tetrahydride; water; sodium methylate; Dess-Martin periodane; toluene-4-sulfonic acid; triethylamine; orthoformic acid triethyl ester; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethylene glycol; acetone;

Reference yield:

: 1264295-96-6
2-methyl-2-(2-methyl-1,3-dioxolan-2-yl)-3-phenylpropanoic acid mono-(dicyclohexylammonium) salt

: 1264296-55-0
2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanal

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride / water

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.17 h / 0 °C / Reflux

2.2: 0 °C

3.1: hydrogenchloride; water / acetone / 1 h

4.1: dmap; triethylamine / dichloromethane / 2 h

5.1: 16 h / 125 °C

6.1: hydrogenchloride / 1,4-dioxane; ethanol / 0.25 h / 150 °C / Irradiation with microwave

7.1: sodium methylate / methanol / 1.5 h

8.1: Dess-Martin periodane; pyridine / dichloromethane / 3 h / 20 °C

8.2: 0.33 h

With pyridine; hydrogenchloride; dmap; lithium aluminium tetrahydride; water; sodium methylate; Dess-Martin periodane; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetone;