2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-N,N,2-trimethyl-3-phenylpropan-1-amine

Base Information

Chemical Name:2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-N,N,2-trimethyl-3-phenylpropan-1-amine
CAS No.:1264295-48-8
Molecular Formula:C₂₄H₂₅ClN₄
Molecular Weight:404.942
Hs Code.:

Synonyms:2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-N,N,2-trimethyl-3-phenylpropan-1-amine

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Chemical Property of 2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-N,N,2-trimethyl-3-phenylpropan-1-amine

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Technology Process of 2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-N,N,2-trimethyl-3-phenylpropan-1-amine

There total 11 articles about 2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-N,N,2-trimethyl-3-phenylpropan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1264296-55-0
2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanal

: 124-40-3
dimethyl amine

: 1264295-48-8
2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-N,N,2-trimethyl-3-phenylpropan-1-amine

Guidance literature:: 2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanal; dimethyl amine; With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; for 3h;

With water; sodium hydroxide; In tetrahydrofuran;

Reference yield:

: 107449-78-5
ethyl α-methyl-α-benzylacetoacetate

: 1264295-48-8
2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-N,N,2-trimethyl-3-phenylpropan-1-amine

Guidance literature:: Multi-step reaction with 11 steps

1.1: toluene-4-sulfonic acid; orthoformic acid triethyl ester / 55 °C

2.1: lithium hydroxide / ethylene glycol / 0.5 h / 200 °C

3.1: hydrogenchloride / water

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.17 h / 0 °C / Reflux

4.2: 0 °C

5.1: hydrogenchloride; water / acetone / 1 h

6.1: dmap; triethylamine / dichloromethane / 2 h

7.1: 16 h / 125 °C

8.1: hydrogenchloride / 1,4-dioxane; ethanol / 0.25 h / 150 °C / Irradiation with microwave

9.1: sodium methylate / methanol / 1.5 h

10.1: Dess-Martin periodane; pyridine / dichloromethane / 3 h / 20 °C

10.2: 0.33 h

11.1: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 3 h

With pyridine; hydrogenchloride; dmap; lithium aluminium tetrahydride; water; sodium methylate; sodium tris(acetoxy)borohydride; Dess-Martin periodane; toluene-4-sulfonic acid; acetic acid; triethylamine; orthoformic acid triethyl ester; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethylene glycol; acetone;

Reference yield:

: 1264295-94-4
ethyl2-methyl-2-(2-methyl-1,3-dioxolan-2-yl)-3-phenylpropanoate

: 1264295-48-8
2-(3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-N,N,2-trimethyl-3-phenylpropan-1-amine

Guidance literature:: Multi-step reaction with 10 steps

1.1: lithium hydroxide / ethylene glycol / 0.5 h / 200 °C

2.1: hydrogenchloride / water

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.17 h / 0 °C / Reflux

3.2: 0 °C

4.1: hydrogenchloride; water / acetone / 1 h

5.1: dmap; triethylamine / dichloromethane / 2 h

6.1: 16 h / 125 °C

7.1: hydrogenchloride / 1,4-dioxane; ethanol / 0.25 h / 150 °C / Irradiation with microwave

8.1: sodium methylate / methanol / 1.5 h

9.1: Dess-Martin periodane; pyridine / dichloromethane / 3 h / 20 °C

9.2: 0.33 h

10.1: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 3 h

With pyridine; hydrogenchloride; dmap; lithium aluminium tetrahydride; water; sodium methylate; sodium tris(acetoxy)borohydride; Dess-Martin periodane; acetic acid; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethylene glycol; acetone;