3-Amino-1-cyclohexyl-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione

Base Information

• Chemical Name: 3-Amino-1-cyclohexyl-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione
• CAS No.: 162271-80-9
• Molecular Formula: C₂₁H₂₈N₄O₃
• Molecular Weight: 384.478

Synonyms:3-Amino-1-cyclohexyl-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione

Chemical Property of 3-Amino-1-cyclohexyl-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione

Chemical Property:

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Technology Process of 3-Amino-1-cyclohexyl-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione

There total 4 articles about 3-Amino-1-cyclohexyl-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1-Cyclohexyl-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-3-(phenyl-hydrazono)-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione; hydrochloride → 3-Amino-1-cyclohexyl-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione (162271-80-9)

Guidance literature:

With acetic acid; zinc;

DOI:10.1016/S0960-894X(96)00613-0

Reference yield:

N-1-cyclohexylbenzene-1,2-diamine (74628-31-2) → 3-Amino-1-cyclohexyl-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione (162271-80-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / K₂CO₃ / dimethylformamide

2: 93 percent / tetrahydrofuran

3: 81 percent / Zn, glacial AcOH

With potassium carbonate; acetic acid; zinc; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(96)00613-0

Reference yield:

bromoacetopyrrolidine (90892-09-4) → 3-Amino-1-cyclohexyl-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione (162271-80-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / K₂CO₃ / dimethylformamide

2: 93 percent / tetrahydrofuran

3: 81 percent / Zn, glacial AcOH

With potassium carbonate; acetic acid; zinc; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(96)00613-0

upstream raw materials:

bromoacetopyrrolidine

N-1-cyclohexylbenzene-1,2-diamine

2-(2-Cyclohexylamino-phenylamino)-1-pyrrolidin-1-yl-ethanone

Downstream raw materials:

[(S)-1-Cyclohexyl-2,4-dioxo-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-carbamic acid (S)-1-phenyl-ethyl ester

(S)-3-Amino-1-cyclohexyl-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione

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