(Z)-2-[(3R,4R,5R)-3,5-bis(tert-butyldimethylsilyloxy)-4-(3-tert-butyldimethylsilyloxypropoxy)-2-methylenecyclohexylidene]ethanol

Base Information

Chemical Name:(Z)-2-[(3R,4R,5R)-3,5-bis(tert-butyldimethylsilyloxy)-4-(3-tert-butyldimethylsilyloxypropoxy)-2-methylenecyclohexylidene]ethanol
CAS No.:200636-42-6
Molecular Formula:C₃₀H₆₂O₅Si₃
Molecular Weight:587.076
Hs Code.:

Synonyms:(Z)-2-[(3R,4R,5R)-3,5-bis(tert-butyldimethylsilyloxy)-4-(3-tert-butyldimethylsilyloxypropoxy)-2-methylenecyclohexylidene]ethanol

Suppliers and Price of (Z)-2-[(3R,4R,5R)-3,5-bis(tert-butyldimethylsilyloxy)-4-(3-tert-butyldimethylsilyloxypropoxy)-2-methylenecyclohexylidene]ethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 11 raw suppliers

Chemical Property of (Z)-2-[(3R,4R,5R)-3,5-bis(tert-butyldimethylsilyloxy)-4-(3-tert-butyldimethylsilyloxypropoxy)-2-methylenecyclohexylidene]ethanol

Chemical Property:

Boiling Point:545.2±50.0 °C(Predicted)
Density:0.94±0.1 g/cm3(Predicted)

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of (Z)-2-[(3R,4R,5R)-3,5-bis(tert-butyldimethylsilyloxy)-4-(3-tert-butyldimethylsilyloxypropoxy)-2-methylenecyclohexylidene]ethanol

There total 17 articles about (Z)-2-[(3R,4R,5R)-3,5-bis(tert-butyldimethylsilyloxy)-4-(3-tert-butyldimethylsilyloxypropoxy)-2-methylenecyclohexylidene]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: C₃₂H₆₄O₆Si₃

: 200636-42-6
(Z)-2-[(3R,4R,5R)-3,5-bis(tert-butyldimethylsilyloxy)-4-(3-tert-butyldimethylsilyloxypropoxy)-2-methylenecyclohexylidene]ethanol

Guidance literature:: With diisobutylaluminium hydride; In toluene; at 20 ℃; for 1h; Inert atmosphere;

Reference yield: 57.0%

: 200636-38-0
(Z,5R,6R,7RS)-5,7-bis(tert-butyldimethylsilyloxy)-6-(3-tert-butyldimethylsilyloxypropoxy)-3-iodonona-2,8-dien-1-ol

: 200636-42-6
(Z)-2-[(3R,4R,5R)-3,5-bis(tert-butyldimethylsilyloxy)-4-(3-tert-butyldimethylsilyloxypropoxy)-2-methylenecyclohexylidene]ethanol

: (Z)-2-[(3S,4R,5R)-3,5-bis(tert-butyldimethylsilyloxy)-4-(3-tert-butyldimethylsilyloxypropoxy)-2-methylenecyclohexylidene]ethanol

Guidance literature:: With triethylamine; bis-triphenylphosphine-palladium(II) chloride; In acetonitrile; for 4h; Heating;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 200636-42-6
(Z)-2-[(3R,4R,5R)-3,5-bis(tert-butyldimethylsilyloxy)-4-(3-tert-butyldimethylsilyloxypropoxy)-2-methylenecyclohexylidene]ethanol

Guidance literature:: Multi-step reaction with 4 steps

2: DDQ

3: 1.) Red-Al, 2.) I₂

4: Pd(PPh₃)4, Et₃N

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
DOI:10.1016/S0960-894X(97)10095-6