2-deoxy-1-O-hexadecanoyl-2-N-hexadecanoylamino-sn-glycero-3-O-benzyl-(N,N-diisopropyl)phosphoramidite

Base Information

Chemical Name:2-deoxy-1-O-hexadecanoyl-2-N-hexadecanoylamino-sn-glycero-3-O-benzyl-(N,N-diisopropyl)phosphoramidite
CAS No.:1034620-13-7
Molecular Formula:C₄₈H₈₉N₂O₅P
Molecular Weight:805.219
Hs Code.:

Synonyms:2-deoxy-1-O-hexadecanoyl-2-N-hexadecanoylamino-sn-glycero-3-O-benzyl-(N,N-diisopropyl)phosphoramidite

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Chemical Property of 2-deoxy-1-O-hexadecanoyl-2-N-hexadecanoylamino-sn-glycero-3-O-benzyl-(N,N-diisopropyl)phosphoramidite

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Technology Process of 2-deoxy-1-O-hexadecanoyl-2-N-hexadecanoylamino-sn-glycero-3-O-benzyl-(N,N-diisopropyl)phosphoramidite

There total 3 articles about 2-deoxy-1-O-hexadecanoyl-2-N-hexadecanoylamino-sn-glycero-3-O-benzyl-(N,N-diisopropyl)phosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 108549-21-9
benzyl-N,N,N',N'-tetraisopropylphosphorodiamidite

: 153053-07-7
2-deoxy-1-O-hexadecanoyl-2-N-hexadecanoylamino-sn-glycerol

: 1034620-13-7
2-deoxy-1-O-hexadecanoyl-2-N-hexadecanoylamino-sn-glycero-3-O-benzyl-(N,N-diisopropyl)phosphoramidite

Guidance literature:: With 1H-tetrazole; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1034620-12-6
3-O-benzyl-2-deoxy-1-O-hexadecanoyl-2-hexadecanoylamino-sn-glycerol

: 1034620-13-7
2-deoxy-1-O-hexadecanoyl-2-N-hexadecanoylamino-sn-glycero-3-O-benzyl-(N,N-diisopropyl)phosphoramidite

Guidance literature:: Multi-step reaction with 2 steps

1: 20% palladium hydroxide-activated charcoal; hydrogen; acetic acid / ethanol / 16 h / 20 °C

2: 1H-tetrazole / dichloromethane / 1 h / 20 °C

With 1H-tetrazole; 20% palladium hydroxide-activated charcoal; hydrogen; acetic acid; In ethanol; dichloromethane;
DOI:10.1021/jm2008419

Reference yield:

: 112-67-4
n-hexadecanoyl chloride

: 1034620-13-7
2-deoxy-1-O-hexadecanoyl-2-N-hexadecanoylamino-sn-glycero-3-O-benzyl-(N,N-diisopropyl)phosphoramidite

Guidance literature:: Multi-step reaction with 3 steps

1: dmap / chloroform / 6 h / 0 - 20 °C

2: 20% palladium hydroxide-activated charcoal; hydrogen; acetic acid / ethanol / 16 h / 20 °C

3: 1H-tetrazole / dichloromethane / 1 h / 20 °C

With 1H-tetrazole; dmap; 20% palladium hydroxide-activated charcoal; hydrogen; acetic acid; In ethanol; dichloromethane; chloroform;
DOI:10.1021/jm2008419