1-[[2-(4-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(hydroxymethyl)phenyl]urea

Base Information

Chemical Name:1-[[2-(4-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(hydroxymethyl)phenyl]urea
CAS No.:1402581-33-2
Molecular Formula:C₁₉H₁₅ClF₄N₄O₂
Molecular Weight:442.8
Hs Code.:

Synonyms:1-[[2-(4-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(hydroxymethyl)phenyl]urea

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Chemical Property of 1-[[2-(4-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(hydroxymethyl)phenyl]urea

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Technology Process of 1-[[2-(4-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(hydroxymethyl)phenyl]urea

There total 6 articles about 1-[[2-(4-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(hydroxymethyl)phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1402585-34-5
C₁₃H₁₂F₄N₄O₂

: 1679-18-1
4-Chlorophenylboronic acid

: 1402581-33-2
1-[[2-(4-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(hydroxymethyl)phenyl]urea

Guidance literature:: With pyridine; copper diacetate; In dichloromethane; at 23 ℃; for 48h;

Reference yield:

: 1254717-57-1
tert-butyl (3-(trifluoromethyl)-1H-pyrazol-5-yl)methylcarbamate

: 1402581-33-2
1-[[2-(4-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(hydroxymethyl)phenyl]urea

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / isopropyl alcohol / 48 h / 23 °C

2: triethylamine / dichloromethane / 16 h / 23 °C

3: pyridine; copper diacetate / dichloromethane / 48 h / 23 °C

With pyridine; hydrogenchloride; copper diacetate; triethylamine; In dichloromethane; isopropyl alcohol;

Reference yield:

: 392-09-6
2-fluoro-4-nitro-benzoic acid methyl ester

: 1402581-33-2
1-[[2-(4-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(hydroxymethyl)phenyl]urea

Guidance literature:: Multi-step reaction with 5 steps

1: methanol; sodium tetrahydroborate / 4 h / 23 °C

2: hydrogen; palladium 10% on activated carbon / ethyl acetate / 6 h / 23 °C

3: pyridine / acetone / 1 h / 0 - 23 °C

4: triethylamine / dichloromethane / 16 h / 23 °C

5: pyridine; copper diacetate / dichloromethane / 48 h / 23 °C

With pyridine; methanol; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; copper diacetate; triethylamine; In dichloromethane; ethyl acetate; acetone;